Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7ZM7

CryoEM structure of mitochondrial complex I from Chaetomium thermophilum (inhibited by DDM)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
11NADH-ubiquinone oxidoreductase chain 1polymer37841716.41UniProt (G1DJA6)
Pfam (PF00146)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND1 of NADH-ubiquinone oxidoreductase (Complex I)
22NADH dehydrogenase subunit 2polymer57164129.21UniProt (G1DJ98)
Pfam (PF00361)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND2 of NADH-ubiquinone oxidoreductase (Complex I)
33NADH-ubiquinone oxidoreductase chain 3polymer14616330.01UniProt (G1DJ99)
Pfam (PF00507)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND3 of NADH-ubiquinone oxidoreductase (Complex I)
44NADH-ubiquinone oxidoreductase chain 4polymer54260810.31UniProt (G1DJA7)
Pfam (PF00361)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND4 of NADH-ubiquinone oxidoreductase (Complex I)
55NADH-ubiquinone oxidoreductase chain 5polymer67975872.01UniProt (G1DJA3)
Pfam (PF00662)
Pfam (PF00361)
Pfam (PF06455)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND5 of NADH-ubiquinone oxidoreductase (Complex I)
66NADH-ubiquinone oxidoreductase chain 6polymer22424819.31UniProt (G1DJ96)
Pfam (PF00499)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND6 of NADH-ubiquinone oxidoreductase (Complex I)
78NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7polymer8610312.81UniProt (G0SAE9)
Pfam (PF05676)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB7 of NADH-ubiquinone oxidoreductase (Complex I)
89Subunit NDUFS5 of NADH-ubiquinone oxidoreductase (Complex I)polymer78587142.31UniProt (G0SG48)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS5 of NADH-ubiquinone oxidoreductase (Complex I)
9ANADH-ubiquinone oxidoreductase-like proteinpolymer74982096.51UniProt (G0RYA1)
Pfam (PF13510)
Pfam (PF10588)
Pfam (PF00384)
Pfam (PF09326)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS1 of NADH-ubiquinone oxidoreductase (Complex I)
10BNADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialpolymer50755453.11UniProt (G0SA46)
Pfam (PF01512)
Pfam (PF10531)
Pfam (PF10589)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFV1 of NADH-ubiquinone oxidoreductase (Complex I)
11CNADH-ubiquinone oxidoreductase 49 kDa subunit-like proteinpolymer49955910.31UniProt (G0SCG0)
Pfam (PF00346)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS2 of NADH-ubiquinone oxidoreductase (Complex I)
12DSubunit NDUFA1 of NADH-ubiquinone oxidoreductase (Complex I)polymer869833.41Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA1 of NADH-ubiquinone oxidoreductase (Complex I)
13ENADH dehydrogenase (Ubiquinone)-like proteinpolymer37843800.91UniProt (G0SB35)
Pfam (PF01370)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA9 of NADH-ubiquinone oxidoreductase (Complex I)
14FNADH-ubiquinone oxidoreductase-like proteinpolymer26129245.01UniProt (G0S8H4)
Pfam (PF04716)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA5 of NADH-ubiquinone oxidoreductase (Complex I)
15GNADH-ubiquinone oxidoreductase 30.4 kDa subunit-like proteinpolymer29333377.11UniProt (G0S8U1)
Pfam (PF00329)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS3 of NADH-ubiquinone oxidoreductase (Complex I)
16HSubunit NDUFV2 of NADH-ubiquinone oxidoreductase (Complex I)polymer31835006.01UniProt (G0SDM6)
Pfam (PF01257)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFV2 of NADH-ubiquinone oxidoreductase (Complex I)
17IOxidoreductase-like proteinpolymer22325415.31UniProt (G0SBG8)
Pfam (PF12838)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS8 of NADH-ubiquinone oxidoreductase (Complex I)
18JNADH-ubiquinone oxidoreductase-like proteinpolymer19921612.61UniProt (G0S2B3)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA11 of NADH-ubiquinone oxidoreductase (Complex I)
19KNADH-ubiquinone oxidoreductase-like proteinpolymer23025549.61UniProt (G0S9I6)
Pfam (PF01058)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS7 of NADH-ubiquinone oxidoreductase (Complex I)
20LNADH-ubiquinone oxidoreductase chain 4Lpolymer899838.01UniProt (G1DJA2)
Pfam (PF00420)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND4L of NADH-ubiquinone oxidoreductase (Complex I)
21MNADH-ubiquinone oxidoreductase-like proteinpolymer16818613.91UniProt (G0S6J1)
Pfam (PF10276)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS6 of NADH-ubiquinone oxidoreductase (Complex I)
22O, QAcyl carrier proteinpolymer14115593.62UniProt (G0SBG9)
Pfam (PF00550)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFAB1 of NADH-ubiquinone oxidoreductase (Complex I)
23PNADH-ubiquinone oxidoreductase B14 subunit-like proteinpolymer12414836.91UniProt (G0S4Q3)
Pfam (PF13233)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA6 of NADH-ubiquinone oxidoreductase (Complex I)
24RComplex I-B22polymer9911636.51UniProt (G0SAY0)
Pfam (PF05347)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB9 of NADH-ubiquinone oxidoreductase (Complex I)
25SComplex I-ESSSpolymer14315847.81UniProt (G0SAN0)
Pfam (PF10183)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB11 of NADH-ubiquinone oxidoreductase (Complex I)
26UNADH-ubiquinone oxidoreductasepolymer18621517.61UniProt (G0S0R3)
Pfam (PF06747)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA8 of NADH-ubiquinone oxidoreductase (Complex I)
27WNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13polymer12114039.21UniProt (G0SB83)
Pfam (PF06212)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA13 of NADH-ubiquinone oxidoreductase (Complex I)
28XNADH-ubiquinone oxidoreductase-like proteinpolymer19121645.51UniProt (G0S0S8)
Pfam (PF10785)
Pfam (PF12853)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NUXM of NADH-ubiquinone oxidoreductase (Complex I)
29YNADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialpolymer21023494.61UniProt (G0S3Y7)
Pfam (PF04800)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS4 of NADH-ubiquinone oxidoreductase (Complex I)
30ZNADH-ubiquinone oxidoreductase-like proteinpolymer19621164.71UniProt (G0SEF0)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA7 of NADH-ubiquinone oxidoreductase (Complex I)
31aNADH dehydrogenase (Ubiquinone)-like proteinpolymer20323239.71UniProt (G0RXU4)
Pfam (PF05821)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB8 of NADH-ubiquinone oxidoreductase (Complex I)
32bSubunit NDUFC2 of NADH-ubiquinone oxidoreductase (Complex I)polymer9410823.51UniProt (G0S812)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFC2 of NADH-ubiquinone oxidoreductase (Complex I)
33cSubunit NDUFB3 of NADH-ubiquinone oxidoreductase (Complex I)polymer9311153.51UniProt (G0S681)
Pfam (PF08122)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB3 of NADH-ubiquinone oxidoreductase (Complex I)
34dSubunit NDUFB10 of NADH-ubiquinone oxidoreductase (Complex I)polymer10512514.31UniProt (G0SEZ1)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB10 of NADH-ubiquinone oxidoreductase (Complex I)
35eSubunit NDUFB2 of NADH-ubiquinone oxidoreductase (Complex I)polymer465278.11Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB2 of NADH-ubiquinone oxidoreductase (Complex I)
36fNADH dehydrogenase-like proteinpolymer9510897.61UniProt (G0S1P3)
Pfam (PF05047)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA2 of NADH-ubiquinone oxidoreductase (Complex I)
37gSubunit NDUFA3 of NADH-ubiquinone oxidoreductase (Complex I)polymer829076.51UniProt (G0RZZ2)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA3 of NADH-ubiquinone oxidoreductase (Complex I)
38hNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunitpolymer13415967.11UniProt (G0S775)
Pfam (PF05071)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA12 of NADH-ubiquinone oxidoreductase (Complex I)
39iSubunit NDUFB6 of NADH-ubiquinone oxidoreductase (Complex I)polymer9310857.31UniProt (G0S569)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB6 of NADH-ubiquinone oxidoreductase (Complex I)
40jSubunit NDUFB4 of NADH-ubiquinone oxidoreductase (Complex I)polymer758760.31UniProt (G0S5C8)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB4 of NADH-ubiquinone oxidoreductase (Complex I)
41nSubunit NDUFB5 of NADH-ubiquinone oxidoreductase (Complex I)polymer18420824.31UniProt (G0S086)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB5 of NADH-ubiquinone oxidoreductase (Complex I)
42oOxidoreductase-like domain-containing proteinpolymer38041609.11UniProt (G0S982)
Pfam (PF09791)
In PDB		Chaetomium thermophilum var. thermophilum DSM 1495Subunit Ct-NDUFV3 of NADH-ubiquinone oxidoreductase (Complex I)
435, 1, 21,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINEnon-polymer790.14Chemie (PC1)
443, 4, X, a, 5...DODECYL-BETA-D-MALTOSIDEnon-polymer510.614Chemie (LMT)
45X, D, 2, SCARDIOLIPINnon-polymer1464.05Chemie (CDL)
46W, 5, i, E, I1,2-Distearoyl-sn-glycerophosphoethanolaminenon-polymer748.18Chemie (3PE)
47A, HFE2/S2 (INORGANIC) CLUSTERnon-polymer175.82Chemie (FES)
48A, B, I, KIRON/SULFUR CLUSTERnon-polymer351.66Chemie (SF4)
49BFLAVIN MONONUCLEOTIDEnon-polymer456.31Chemie (FMN)
50ENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer745.41Chemie (NDP)
51MZINC IONnon-polymer65.41Chemie (ZN)
52O, QS-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioatenon-polymer568.72Chemie (ZMP)
53waterwater18.01219Chemie (HOH)
Sequence modifications
5: 1 - 679 (UniProt: G1DJA3)
PDBExternal DatabaseDetails
Arg 445-insertion
Leu 446-insertion
Ala 447-insertion
Ile 448-insertion
Asp 449-insertion
Asn 450-insertion
Phe 451-insertion
Phe 452-insertion
Ser 453-insertion
Ala 454-insertion
Gln 455-insertion
Ala 456-insertion
Ile 457-insertion
Lys 458-insertion
9: 1 - 785 (UniProt: G0SG48)
PDBExternal DatabaseDetails
Val 100-insertion
A: 1 - 749 (UniProt: G0RYA1)
PDBExternal DatabaseDetails
-Gln 72deletion
Tyr 72Val 73conflict
Cys 73Ser 74conflict
Tyr 74Met 75conflict
His 75Arg 76conflict
Glu 76Arg 77conflict
C: 1 - 499 (UniProt: G0SCG0)
PDBExternal DatabaseDetails
-Lys 248deletion
-Leu 249deletion
-Thr 250deletion
-Ile 251deletion
-Ala 252deletion
-Pro 253deletion
-Lys 254deletion
E: 1 - 378 (UniProt: G0SB35)
PDBExternal DatabaseDetails
Glu 103-insertion
Phe 104-insertion
Asp 105-insertion
Leu 106-insertion
Arg 107-insertion
Asn 108-insertion
Thr 109-insertion
Gln 110-insertion
His 233-insertion
Val 234-insertion
M: 1 - 149 (UniProt: G0S6J1)
PDBExternal DatabaseDetails
Ala 149Ser 149conflict
Asn 150-insertion
Glu 151-insertion
His 152-insertion
His 153-insertion
Arg 154-insertion
Lys 155-insertion
Tyr 156-insertion
Leu 157-insertion
Glu 158-insertion
Ser 159-insertion
Leu 160-insertion
Pro 161-insertion
Gln 162-insertion
Thr 163-insertion
Ser 164-insertion
Tyr 165-insertion
Pro 166-insertion
Leu 167-insertion
Asn 168-insertion
Z: 1 - 188 (UniProt: G0SEF0)
PDBExternal DatabaseDetails
Ser 189-insertion
Tyr 190-insertion
Pro 191-insertion
Cys 192-insertion
Arg 193-insertion
Ser 194-insertion
Phe 195-insertion
Val 196-insertion
a: 1 - 203 (UniProt: G0RXU4)
PDBExternal DatabaseDetails
Val 166Ala 166conflict
Ala 168Met 168conflict
-Glu 169deletion
-Gly 170deletion
-Asp 171deletion
-Pro 172deletion
-Asp 173deletion
-Pro 174deletion
f: 1 - 95 (UniProt: G0S1P3)
PDBExternal DatabaseDetails
-Ala 65deletion
n: 53 - 184 (UniProt: G0S086)
PDBExternal DatabaseDetails
Met 1-initiating methionine
Leu 2-insertion
Ala 3-insertion
Leu 4-insertion
Arg 5-insertion
Gln 6-insertion
Arg 7-insertion
Ala 8-insertion
Ala 9-insertion
Leu 10-insertion
Leu 11-insertion
Ala 12-insertion
Arg 13-insertion
Arg 14-insertion
Val 15-insertion
Arg 16-insertion
Pro 17-insertion
Thr 18-insertion
Val 19-insertion
Val 20-insertion
Val 21-insertion
Pro 22-insertion
Arg 23-insertion
Asn 24-insertion
Ala 25-insertion
Arg 26-insertion
Thr 27-insertion
Tyr 28-insertion
Ala 29-insertion
Ser 30-insertion
Ser 31-insertion
His 32-insertion
Asp 33-insertion
His 34-insertion
Asp 35-insertion
His 36-insertion
His 37-insertion
Asp 38-insertion
His 39-insertion
His 40-insertion
His 41-insertion
Asp 42-insertion
His 43-insertion
Gly 44-insertion
His 45-insertion
Asn 46-insertion
Val 47-insertion
Glu 48-insertion
Glu 49-insertion
Pro 50-insertion
Leu 51-insertion
Gly 52-insertion
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains43
Total formula weight1183255.3
Non-Polymers*Number of molecules44
Total formula weight28480.0
All*Total formula weight1211735.3
*Water molecules are not included.

219515

PDB entries from 2024-05-08

PDB statisticsPDBj update infoContact PDBjnumon