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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7ZM7

CryoEM structure of mitochondrial complex I from Chaetomium thermophilum (inhibited by DDM)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(1)		NADH-ubiquinone oxidoreductase chain 1polymer37841716.41UniProt (G1DJA6)
Pfam (PF00146)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND1 of NADH-ubiquinone oxidoreductase (Complex I)
2B
(2)		NADH dehydrogenase subunit 2polymer57164129.21UniProt (G1DJ98)
Pfam (PF00361)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND2 of NADH-ubiquinone oxidoreductase (Complex I)
3C
(3)		NADH-ubiquinone oxidoreductase chain 3polymer14616330.01UniProt (G1DJ99)
Pfam (PF00507)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND3 of NADH-ubiquinone oxidoreductase (Complex I)
4D
(4)		NADH-ubiquinone oxidoreductase chain 4polymer54260810.31UniProt (G1DJA7)
Pfam (PF00361)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND4 of NADH-ubiquinone oxidoreductase (Complex I)
5E
(5)		NADH-ubiquinone oxidoreductase chain 5polymer67975872.01UniProt (G1DJA3)
Pfam (PF00662)
Pfam (PF00361)
Pfam (PF06455)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND5 of NADH-ubiquinone oxidoreductase (Complex I)
6F
(6)		NADH-ubiquinone oxidoreductase chain 6polymer22424819.31UniProt (G1DJ96)
Pfam (PF00499)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND6 of NADH-ubiquinone oxidoreductase (Complex I)
7G
(8)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7polymer8610312.81UniProt (G0SAE9)
Pfam (PF05676)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB7 of NADH-ubiquinone oxidoreductase (Complex I)
8H
(9)		Subunit NDUFS5 of NADH-ubiquinone oxidoreductase (Complex I)polymer78587142.31UniProt (G0SG48)Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS5 of NADH-ubiquinone oxidoreductase (Complex I)
9I
(A)		NADH-ubiquinone oxidoreductase-like proteinpolymer74982096.51UniProt (G0RYA1)
Pfam (PF13510)
Pfam (PF10588)
Pfam (PF22117)
Pfam (PF22151)
Pfam (PF00384)
Pfam (PF09326)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS1 of NADH-ubiquinone oxidoreductase (Complex I)
10J
(B)		NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialpolymer50755453.11UniProt (G0SA46)
Pfam (PF01512)
Pfam (PF22461)
Pfam (PF10531)
Pfam (PF10589)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFV1 of NADH-ubiquinone oxidoreductase (Complex I)
11K
(C)		NADH-ubiquinone oxidoreductase 49 kDa subunit-like proteinpolymer49955910.31UniProt (G0SCG0)
Pfam (PF00346)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS2 of NADH-ubiquinone oxidoreductase (Complex I)
12L
(D)		Subunit NDUFA1 of NADH-ubiquinone oxidoreductase (Complex I)polymer869833.41Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA1 of NADH-ubiquinone oxidoreductase (Complex I)
13M
(E)		NADH dehydrogenase (Ubiquinone)-like proteinpolymer37843800.91UniProt (G0SB35)
Pfam (PF01370)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA9 of NADH-ubiquinone oxidoreductase (Complex I)
14N
(F)		NADH-ubiquinone oxidoreductase-like proteinpolymer26129245.01UniProt (G0S8H4)
Pfam (PF04716)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA5 of NADH-ubiquinone oxidoreductase (Complex I)
15O
(G)		NADH-ubiquinone oxidoreductase 30.4 kDa subunit-like proteinpolymer29333377.11UniProt (G0S8U1)
Pfam (PF00329)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS3 of NADH-ubiquinone oxidoreductase (Complex I)
16P
(H)		Subunit NDUFV2 of NADH-ubiquinone oxidoreductase (Complex I)polymer31835006.01UniProt (G0SDM6)
Pfam (PF01257)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFV2 of NADH-ubiquinone oxidoreductase (Complex I)
17Q
(I)		Oxidoreductase-like proteinpolymer22325415.31UniProt (G0SBG8)
Pfam (PF12838)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS8 of NADH-ubiquinone oxidoreductase (Complex I)
18R
(J)		NADH-ubiquinone oxidoreductase-like proteinpolymer19921612.61UniProt (G0S2B3)Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA11 of NADH-ubiquinone oxidoreductase (Complex I)
19S
(K)		NADH-ubiquinone oxidoreductase-like proteinpolymer23025549.61UniProt (G0S9I6)
Pfam (PF01058)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS7 of NADH-ubiquinone oxidoreductase (Complex I)
20T
(L)		NADH-ubiquinone oxidoreductase chain 4Lpolymer899838.01UniProt (G1DJA2)
Pfam (PF00420)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit ND4L of NADH-ubiquinone oxidoreductase (Complex I)
21U
(M)		NADH-ubiquinone oxidoreductase-like proteinpolymer16818613.91UniProt (G0S6J1)
Pfam (PF10276)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS6 of NADH-ubiquinone oxidoreductase (Complex I)
22V, X
(O, Q)		Acyl carrier proteinpolymer14115593.62UniProt (G0SBG9)
Pfam (PF00550)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFAB1 of NADH-ubiquinone oxidoreductase (Complex I)
23W
(P)		NADH-ubiquinone oxidoreductase B14 subunit-like proteinpolymer12414836.91UniProt (G0S4Q3)
Pfam (PF13233)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA6 of NADH-ubiquinone oxidoreductase (Complex I)
24Y
(R)		Complex I-B22polymer9911636.51UniProt (G0SAY0)
Pfam (PF05347)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB9 of NADH-ubiquinone oxidoreductase (Complex I)
25Z
(S)		Complex I-ESSSpolymer14315847.81UniProt (G0SAN0)
Pfam (PF10183)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB11 of NADH-ubiquinone oxidoreductase (Complex I)
26AA
(U)		NADH-ubiquinone oxidoreductasepolymer18621517.61UniProt (G0S0R3)
Pfam (PF06747)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA8 of NADH-ubiquinone oxidoreductase (Complex I)
27BA
(W)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13polymer12114039.21UniProt (G0SB83)
Pfam (PF06212)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA13 of NADH-ubiquinone oxidoreductase (Complex I)
28CA
(X)		NADH-ubiquinone oxidoreductase-like proteinpolymer19121645.51UniProt (G0S0S8)
Pfam (PF10785)
Pfam (PF12853)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NUXM of NADH-ubiquinone oxidoreductase (Complex I)
29DA
(Y)		NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialpolymer21023494.61UniProt (G0S3Y7)
Pfam (PF04800)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFS4 of NADH-ubiquinone oxidoreductase (Complex I)
30EA
(Z)		NADH-ubiquinone oxidoreductase-like proteinpolymer19621164.71UniProt (G0SEF0)Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA7 of NADH-ubiquinone oxidoreductase (Complex I)
31FA
(a)		NADH dehydrogenase (Ubiquinone)-like proteinpolymer20323239.71UniProt (G0RXU4)
Pfam (PF05821)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB8 of NADH-ubiquinone oxidoreductase (Complex I)
32GA
(b)		Subunit NDUFC2 of NADH-ubiquinone oxidoreductase (Complex I)polymer9410823.51UniProt (G0S812)Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFC2 of NADH-ubiquinone oxidoreductase (Complex I)
33HA
(c)		Subunit NDUFB3 of NADH-ubiquinone oxidoreductase (Complex I)polymer9311153.51UniProt (G0S681)
Pfam (PF08122)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB3 of NADH-ubiquinone oxidoreductase (Complex I)
34IA
(d)		Subunit NDUFB10 of NADH-ubiquinone oxidoreductase (Complex I)polymer10512514.31UniProt (G0SEZ1)Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB10 of NADH-ubiquinone oxidoreductase (Complex I)
35JA
(e)		Subunit NDUFB2 of NADH-ubiquinone oxidoreductase (Complex I)polymer465278.11Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB2 of NADH-ubiquinone oxidoreductase (Complex I)
36KA
(f)		NADH dehydrogenase-like proteinpolymer9510897.61UniProt (G0S1P3)
Pfam (PF05047)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA2 of NADH-ubiquinone oxidoreductase (Complex I)
37LA
(g)		Subunit NDUFA3 of NADH-ubiquinone oxidoreductase (Complex I)polymer829076.51UniProt (G0RZZ2)Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA3 of NADH-ubiquinone oxidoreductase (Complex I)
38MA
(h)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunitpolymer13415967.11UniProt (G0S775)
Pfam (PF05071)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFA12 of NADH-ubiquinone oxidoreductase (Complex I)
39NA
(i)		Subunit NDUFB6 of NADH-ubiquinone oxidoreductase (Complex I)polymer9310857.31UniProt (G0S569)Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB6 of NADH-ubiquinone oxidoreductase (Complex I)
40OA
(j)		Subunit NDUFB4 of NADH-ubiquinone oxidoreductase (Complex I)polymer758760.31UniProt (G0S5C8)Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB4 of NADH-ubiquinone oxidoreductase (Complex I)
41PA
(n)		Subunit NDUFB5 of NADH-ubiquinone oxidoreductase (Complex I)polymer18420824.31UniProt (G0S086)Chaetomium thermophilum var. thermophilum DSM 1495Subunit NDUFB5 of NADH-ubiquinone oxidoreductase (Complex I)
42QA
(o)		Oxidoreductase-like domain-containing proteinpolymer38041609.11UniProt (G0S982)
Pfam (PF09791)		Chaetomium thermophilum var. thermophilum DSM 1495Subunit Ct-NDUFV3 of NADH-ubiquinone oxidoreductase (Complex I)
43DB, EB, RA, YA
(5, 1, 2)		1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINEnon-polymer790.14Chemie (PC1)
44AB, BB, EC, FC, GB...
(3, 4, X, a, 5...)		DODECYL-BETA-D-MALTOSIDEnon-polymer510.614Chemie (LMT)
45CC, DC, NB, UA, ZB
(X, D, 2, S)		CARDIOLIPINnon-polymer1464.05Chemie (CDL)
46AC, BC, CB, FB, HB...
(W, 5, i, E, I)		1,2-Distearoyl-sn-glycerophosphoethanolaminenon-polymer748.18Chemie (3PE)
47IB, QB
(A, H)		FE2/S2 (INORGANIC) CLUSTERnon-polymer175.82Chemie (FES)
48JB, KB, LB, RB, SB...
(A, B, I, K)		IRON/SULFUR CLUSTERnon-polymer351.66Chemie (SF4)
49MB
(B)		FLAVIN MONONUCLEOTIDEnon-polymer456.31Chemie (FMN)
50PB
(E)		NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer745.41Chemie (NDP)
51WB
(M)		ZINC IONnon-polymer65.41Chemie (ZN)
52XB, YB
(O, Q)		S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioatenon-polymer568.72Chemie (ZMP)
53AD, BD, CD, DD, ED...
(K, L, M, P, R...)		waterwater18.01219Chemie (HOH)
Sequence modifications
5: 1 - 679 (UniProt: G1DJA3)
PDBExternal DatabaseDetails
Arg 445-insertion
Leu 446-insertion
Ala 447-insertion
Ile 448-insertion
Asp 449-insertion
Asn 450-insertion
Phe 451-insertion
Phe 452-insertion
Ser 453-insertion
Ala 454-insertion
Gln 455-insertion
Ala 456-insertion
Ile 457-insertion
Lys 458-insertion
9: 1 - 785 (UniProt: G0SG48)
PDBExternal DatabaseDetails
Val 100-insertion
A: 1 - 749 (UniProt: G0RYA1)
PDBExternal DatabaseDetails
-Gln 72deletion
Tyr 72Val 73conflict
Cys 73Ser 74conflict
Tyr 74Met 75conflict
His 75Arg 76conflict
Glu 76Arg 77conflict
C: 1 - 499 (UniProt: G0SCG0)
PDBExternal DatabaseDetails
-Lys 248deletion
-Leu 249deletion
-Thr 250deletion
-Ile 251deletion
-Ala 252deletion
-Pro 253deletion
-Lys 254deletion
E: 1 - 378 (UniProt: G0SB35)
PDBExternal DatabaseDetails
Glu 103-insertion
Phe 104-insertion
Asp 105-insertion
Leu 106-insertion
Arg 107-insertion
Asn 108-insertion
Thr 109-insertion
Gln 110-insertion
His 233-insertion
Val 234-insertion
M: 1 - 149 (UniProt: G0S6J1)
PDBExternal DatabaseDetails
Ala 149Ser 149conflict
Asn 150-insertion
Glu 151-insertion
His 152-insertion
His 153-insertion
Arg 154-insertion
Lys 155-insertion
Tyr 156-insertion
Leu 157-insertion
Glu 158-insertion
Ser 159-insertion
Leu 160-insertion
Pro 161-insertion
Gln 162-insertion
Thr 163-insertion
Ser 164-insertion
Tyr 165-insertion
Pro 166-insertion
Leu 167-insertion
Asn 168-insertion
Z: 1 - 188 (UniProt: G0SEF0)
PDBExternal DatabaseDetails
Ser 189-insertion
Tyr 190-insertion
Pro 191-insertion
Cys 192-insertion
Arg 193-insertion
Ser 194-insertion
Phe 195-insertion
Val 196-insertion
a: 1 - 203 (UniProt: G0RXU4)
PDBExternal DatabaseDetails
Val 166Ala 166conflict
Ala 168Met 168conflict
-Glu 169deletion
-Gly 170deletion
-Asp 171deletion
-Pro 172deletion
-Asp 173deletion
-Pro 174deletion
f: 1 - 95 (UniProt: G0S1P3)
PDBExternal DatabaseDetails
-Ala 65deletion
n: 53 - 184 (UniProt: G0S086)
PDBExternal DatabaseDetails
Met 1-initiating methionine
Leu 2-insertion
Ala 3-insertion
Leu 4-insertion
Arg 5-insertion
Gln 6-insertion
Arg 7-insertion
Ala 8-insertion
Ala 9-insertion
Leu 10-insertion
Leu 11-insertion
Ala 12-insertion
Arg 13-insertion
Arg 14-insertion
Val 15-insertion
Arg 16-insertion
Pro 17-insertion
Thr 18-insertion
Val 19-insertion
Val 20-insertion
Val 21-insertion
Pro 22-insertion
Arg 23-insertion
Asn 24-insertion
Ala 25-insertion
Arg 26-insertion
Thr 27-insertion
Tyr 28-insertion
Ala 29-insertion
Ser 30-insertion
Ser 31-insertion
His 32-insertion
Asp 33-insertion
His 34-insertion
Asp 35-insertion
His 36-insertion
His 37-insertion
Asp 38-insertion
His 39-insertion
His 40-insertion
His 41-insertion
Asp 42-insertion
His 43-insertion
Gly 44-insertion
His 45-insertion
Asn 46-insertion
Val 47-insertion
Glu 48-insertion
Glu 49-insertion
Pro 50-insertion
Leu 51-insertion
Gly 52-insertion
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains43
Total formula weight1183255.3
Non-Polymers*Number of molecules44
Total formula weight28480.0
All*Total formula weight1211735.3
*Water molecules are not included.

237735

PDB entries from 2025-06-18

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