Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7ZM7

CryoEM structure of mitochondrial complex I from Chaetomium thermophilum (inhibited by DDM)

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0003954	molecular_function	NADH dehydrogenase activity
1	0005743	cellular_component	mitochondrial inner membrane
1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1	0009060	biological_process	aerobic respiration
1	0016020	cellular_component	membrane
1	1902600	biological_process	proton transmembrane transport
2	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
2	0016020	cellular_component	membrane
2	0042773	biological_process	ATP synthesis coupled electron transport
2	1902600	biological_process	proton transmembrane transport
3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
3	0016020	cellular_component	membrane
3	0030964	cellular_component	NADH dehydrogenase complex
3	0031966	cellular_component	mitochondrial membrane
3	1902600	biological_process	proton transmembrane transport
4	0003954	molecular_function	NADH dehydrogenase activity
4	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
4	0009060	biological_process	aerobic respiration
4	0015990	biological_process	electron transport coupled proton transport
4	0016020	cellular_component	membrane
4	0031966	cellular_component	mitochondrial membrane
4	0042773	biological_process	ATP synthesis coupled electron transport
4	0048039	molecular_function	ubiquinone binding
5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
5	0042773	biological_process	ATP synthesis coupled electron transport
6	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
6	0031966	cellular_component	mitochondrial membrane
6	1902600	biological_process	proton transmembrane transport
8	0005739	cellular_component	mitochondrion
8	0005743	cellular_component	mitochondrial inner membrane
8	0005758	cellular_component	mitochondrial intermembrane space
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
A	0042773	biological_process	ATP synthesis coupled electron transport
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	1902600	biological_process	proton transmembrane transport
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0010181	molecular_function	FMN binding
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0048038	molecular_function	quinone binding
C	0051287	molecular_function	NAD binding
F	0005743	cellular_component	mitochondrial inner membrane
F	0022904	biological_process	respiratory electron transport chain
G	0005739	cellular_component	mitochondrion
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0016020	cellular_component	membrane
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	1902600	biological_process	proton transmembrane transport
H	0005743	cellular_component	mitochondrial inner membrane
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0016491	molecular_function	oxidoreductase activity
H	0046872	molecular_function	metal ion binding
H	0051536	molecular_function	iron-sulfur cluster binding
H	0051537	molecular_function	2 iron, 2 sulfur cluster binding
H	0098796	cellular_component	membrane protein complex
H	1902494	cellular_component	catalytic complex
H	1902600	biological_process	proton transmembrane transport
I	0016020	cellular_component	membrane
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
J	0005743	cellular_component	mitochondrial inner membrane
J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
J	0045271	cellular_component	respiratory chain complex I
K	0005739	cellular_component	mitochondrion
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0009060	biological_process	aerobic respiration
K	0015990	biological_process	electron transport coupled proton transport
K	0032981	biological_process	mitochondrial respiratory chain complex I assembly
K	0045271	cellular_component	respiratory chain complex I
K	0046872	molecular_function	metal ion binding
K	0048038	molecular_function	quinone binding
K	0051536	molecular_function	iron-sulfur cluster binding
K	0051539	molecular_function	4 iron, 4 sulfur cluster binding
L	0005743	cellular_component	mitochondrial inner membrane
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
L	0030964	cellular_component	NADH dehydrogenase complex
L	0031966	cellular_component	mitochondrial membrane
L	0042773	biological_process	ATP synthesis coupled electron transport
L	1902600	biological_process	proton transmembrane transport
O	0000035	molecular_function	acyl binding
O	0000036	molecular_function	acyl carrier activity
O	0005739	cellular_component	mitochondrion
O	0006629	biological_process	lipid metabolic process
O	0006631	biological_process	fatty acid metabolic process
O	0006633	biological_process	fatty acid biosynthetic process
O	0099128	cellular_component	mitochondrial [2Fe-2S] assembly complex
P	0005743	cellular_component	mitochondrial inner membrane
P	0006979	biological_process	response to oxidative stress
P	0045271	cellular_component	respiratory chain complex I
Q	0000035	molecular_function	acyl binding
Q	0000036	molecular_function	acyl carrier activity
Q	0005739	cellular_component	mitochondrion
Q	0006629	biological_process	lipid metabolic process
Q	0006631	biological_process	fatty acid metabolic process
Q	0006633	biological_process	fatty acid biosynthetic process
Q	0099128	cellular_component	mitochondrial [2Fe-2S] assembly complex
R	0005743	cellular_component	mitochondrial inner membrane
R	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0005743	cellular_component	mitochondrial inner membrane
U	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0016020	cellular_component	membrane
W	0045271	cellular_component	respiratory chain complex I
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0016020	cellular_component	membrane
Y	0022900	biological_process	electron transport chain
a	0005739	cellular_component	mitochondrion
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0022900	biological_process	electron transport chain
c	0032981	biological_process	mitochondrial respiratory chain complex I assembly
d	0005743	cellular_component	mitochondrial inner membrane
e	0005743	cellular_component	mitochondrial inner membrane
e	0045271	cellular_component	respiratory chain complex I
f	0005743	cellular_component	mitochondrial inner membrane
h	0016020	cellular_component	membrane
h	0045271	cellular_component	respiratory chain complex I
n	0005739	cellular_component	mitochondrion
o	0005739	cellular_component	mitochondrion

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDTVEVVMAI

Chain	Residue	Details
O	ASP93-ILE108

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
I	CYS124-PRO135
I	CYS163-PRO174

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLcEyK

Chain	Residue	Details
C	LEU152-LYS163

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREvyDMFgvlfvgHpdlRrIM

Chain	Residue	Details
G	GLU191-MET212

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PryCYheklaiaGnCRmC

Chain	Residue	Details
A	PRO70-CYS87

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
A	CYS137-GLN149

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF

Chain	Residue	Details
A	ARG186-PHE196

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYVCGEETSLIES

Chain	Residue	Details
B	GLY226-SER241

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
B	GLU403-GLY414

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQaFaDALKLLlKE

Chain	Residue	Details
1	GLY51-GLU66

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLAEAEseLVs.G

Chain	Residue	Details
1	PRO206-GLY219

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DglFTfieveCLGaCvnAP

Chain	Residue	Details
H	ASP231-PRO249

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDVYvPgCPP

Chain	Residue	Details
K	GLY186-PRO202

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)