7ZFM
Engineered Protein Targeting the Zika Viral Envelope Fusion Loop
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Peptidyl-prolyl cis-trans isomerase A | polymer | 191 | 20675.0 | 2 | UniProt (P0AFL3) Pfam (PF00160) In PDB | Escherichia coli K-12 | PPIase A,Cyclophilin A,Rotamase A,ZVAP3 |
| 2 | B, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 3 | A | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
| 4 | A, B | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 5 | A | ACETIC ACID | non-polymer | 60.1 | 3 | Chemie (ACY) | |||
| 6 | A, B | SUCCINIC ACID | non-polymer | 118.1 | 2 | Chemie (SIN) | |||
| 7 | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 163 (UniProt: P0AFL3)
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | initiating methionine |
| Gly -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Ser -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Val -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Arg -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ser 22 | Lys 46 | engineered mutation |
| Leu 33 | Val 57 | engineered mutation |
| Asn 38 | Ser 62 | engineered mutation |
| Ser 48 | Arg 72 | engineered mutation |
| Tyr 53 | Phe 77 | engineered mutation |
| Tyr 60 | Phe 84 | engineered mutation |
| Asp 63 | Gln 87 | engineered mutation |
| Gln 68 | Lys 92 | engineered mutation |
| Met 91 | Ala 115 | engineered mutation |
| Glu 94 | Ala 118 | engineered mutation |
| Tyr 112 | Phe 136 | engineered mutation |
| Ala 113 | Leu 137 | engineered mutation |
| Thr 118 | Arg 142 | engineered mutation |
| Arg 119 | Asp 143 | engineered mutation |
| Tyr 120 | Phe 144 | engineered mutation |
| Phe 122 | Tyr 146 | engineered mutation |
| Ser 151 | Asn 175 | engineered mutation |
| Thr 163 | Lys 187 | engineered mutation |
| Val 164 | - | expression tag |
| Leu 165 | - | expression tag |
| Pro 166 | - | expression tag |
| Gly 167 | - | expression tag |
| Ser 168 | - | expression tag |
| Gly 169 | - | expression tag |
| Cys 170 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41350.0 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 2054.2 | |
| All* | Total formula weight | 43404.2 |
