7ZAY

Human heparan sulfate polymerase complex EXT1-EXT2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Exostosin-1	polymer	736	85261.9	1	UniProt (Q16394) Pfam (PF03016) Pfam (PF09258)	Homo sapiens (human)	Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase,Multiple exostoses protein 1,Putative tumor suppressor protein EXT1
2	B (B)	Exostosin-2	polymer	690	79056.8	1	UniProt (Q93063) Pfam (PF03016) Pfam (PF09258)	Homo sapiens (human)	Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase,Multiple exostoses protein 2,Putative tumor suppressor protein EXT2
3	C (C)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
4	D (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
5	E (A)	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	1	Chemie (UDP)

Sequence modifications

A: 29 - 746 (UniProt: Q16394)

PDB	External Database	Details
Gly 26	-	expression tag
Ala 27	-	expression tag
Ser 28	-	expression tag
Asn 747	-	expression tag
Asn 748	-	expression tag
Asn 749	-	expression tag
Asn 750	-	expression tag
Asn 751	-	expression tag
Asn 752	-	expression tag
Gly 753	-	expression tag
His 754	-	expression tag
His 755	-	expression tag
His 756	-	expression tag
His 757	-	expression tag
His 758	-	expression tag
His 759	-	expression tag
His 760	-	expression tag
His 761	-	expression tag

B: 47 - 718 (UniProt: Q93063)

PDB	External Database	Details
Gly 44	-	expression tag
Ala 45	-	expression tag
Ser 46	-	expression tag
Asn 719	-	expression tag
Asn 720	-	expression tag
Asn 721	-	expression tag
Asn 722	-	expression tag
Asn 723	-	expression tag
Asn 724	-	expression tag
Gly 725	-	expression tag
His 726	-	expression tag
His 727	-	expression tag
His 728	-	expression tag
His 729	-	expression tag
His 730	-	expression tag
His 731	-	expression tag
His 732	-	expression tag
His 733	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	164318.7
Branched	Number of molecules	1
	Total formula weight	586.5
Non-Polymers*	Number of molecules	2
	Total formula weight	625.4
All*	Total formula weight	165530.6

*Water molecules are not included.