7ZAY
Human heparan sulfate polymerase complex EXT1-EXT2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Exostosin-1 | polymer | 736 | 85261.9 | 1 | UniProt (Q16394) Pfam (PF03016) Pfam (PF09258) | Homo sapiens (human) | Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase,Multiple exostoses protein 1,Putative tumor suppressor protein EXT1 |
| 2 | B (B) | Exostosin-2 | polymer | 690 | 79056.8 | 1 | UniProt (Q93063) Pfam (PF03016) Pfam (PF09258) | Homo sapiens (human) | Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase,Multiple exostoses protein 2,Putative tumor suppressor protein EXT2 |
| 3 | C (C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E (A) | URIDINE-5'-DIPHOSPHATE | non-polymer | 404.2 | 1 | Chemie (UDP) PubChem (1158) PubChem (6031) PubChem (3084486) PubChem (6101632) PubChem (6604175) PubChem (11811538) PubChem (12049241) PubChem (25323044) PubChem (25323048) PubChem (44298965) PubChem (57448939) PubChem (53486216) PubChem (60098857) PubChem (91746160) PubChem (92332560) PubChem (92332561) PubChem (92332562) PubChem (92332563) PubChem (93088131) PubChem (93630083) |
Sequence modifications
A: 29 - 746 (UniProt: Q16394)
B: 47 - 718 (UniProt: Q93063)
| PDB | External Database | Details |
|---|---|---|
| Gly 26 | - | expression tag |
| Ala 27 | - | expression tag |
| Ser 28 | - | expression tag |
| Asn 747 | - | expression tag |
| Asn 748 | - | expression tag |
| Asn 749 | - | expression tag |
| Asn 750 | - | expression tag |
| Asn 751 | - | expression tag |
| Asn 752 | - | expression tag |
| Gly 753 | - | expression tag |
| His 754 | - | expression tag |
| His 755 | - | expression tag |
| His 756 | - | expression tag |
| His 757 | - | expression tag |
| His 758 | - | expression tag |
| His 759 | - | expression tag |
| His 760 | - | expression tag |
| His 761 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 44 | - | expression tag |
| Ala 45 | - | expression tag |
| Ser 46 | - | expression tag |
| Asn 719 | - | expression tag |
| Asn 720 | - | expression tag |
| Asn 721 | - | expression tag |
| Asn 722 | - | expression tag |
| Asn 723 | - | expression tag |
| Asn 724 | - | expression tag |
| Gly 725 | - | expression tag |
| His 726 | - | expression tag |
| His 727 | - | expression tag |
| His 728 | - | expression tag |
| His 729 | - | expression tag |
| His 730 | - | expression tag |
| His 731 | - | expression tag |
| His 732 | - | expression tag |
| His 733 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 164318.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 625.4 | |
| All* | Total formula weight | 165530.6 |
