7Z8F

Composite structure of dynein-dynactin-BICDR on microtubules

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	ARP1 actin related protein 1 homolog A	polymer	376	42670.7	8	UniProt (F2Z5G5) Pfam (PF00022) In PDB	Sus scrofa (pig)
2	H	Actin, cytoplasmic 1	polymer	375	41782.7	1	UniProt (Q6QAQ1) Pfam (PF00022) In PDB	Sus scrofa (pig)	Beta-actin
3	J	Arp11	polymer	417	46250.8	1	UniProt (I3LHK5) Pfam (PF00022) In PDB	Sus scrofa (pig)
4	K	Capping protein (Actin filament) muscle Z-line, alpha 1	polymer	286	33059.8	1	UniProt (A0PFK5) Pfam (PF01267) In PDB	Sus scrofa (pig)	F-actin capping protein alpha 1 subunit,F-actin capping protein subunit alpha 1
5	L	F-actin capping protein beta subunit	polymer	272	30669.8	1	UniProt (A9XFX6) Pfam (PF01115) UniProt (by SIFTS) (A0PFK7) In PDB	Sus scrofa (pig)	F-actin-capping protein subunit beta,F-actin-capping protein subunit beta isoform 1
6	M, N, P, Q	Dynactin subunit 2	polymer	405	44704.4	4	UniProt (A0A5G2QD80) Pfam (PF04912) In PDB	Sus scrofa (pig)
7	O, R	Dynactin subunit 3	polymer	186	21192.5	2	UniProt (F1SEC0) Pfam (PF07426) In PDB	Sus scrofa (pig)	Dynactin subunit 3 isoform 1
8	S, T	Dynactin subunit 1	polymer	1281	142015.5	2	UniProt (A0A8D1D718) Pfam (PF01302) Pfam (PF12455) UniProt (by SIFTS) (A0A287B8J2) In PDB	Sus scrofa (pig)
9	U	Dynactin 6	polymer	190	20703.9	1	UniProt (D0G6S1) In PDB	Sus scrofa (pig)
10	V	Dynactin subunit 5	polymer	182	20150.5	1	UniProt (A0A286ZK88) Pfam (PF21711) In PDB	Sus scrofa (pig)
11	W, X, w, x	BICD family-like cargo adapter 1	polymer	577	65377.0	4	UniProt (A0JNT9) In PDB	Mus musculus (house mouse)	Bicaudal D-related protein 1,BICDR-1,Coiled-coil domain-containing protein 64A
12	Y	Dynactin subunit 4	polymer	467	52920.4	1	UniProt (A0A4X1TB62) Pfam (PF05502) In PDB	Sus scrofa (pig)	Dynactin subunit 4
13	e, f, m, n	Cytoplasmic dynein 1 heavy chain 1	polymer	4646	533055.1	4	UniProt (Q14204) Pfam (PF08385) Pfam (PF08393) Pfam (PF12774) Pfam (PF17852) Pfam (PF12775) Pfam (PF22597) Pfam (PF12780) Pfam (PF12777) Pfam (PF12781) Pfam (PF03028) Pfam (PF18198) Pfam (PF18199) In PDB	Homo sapiens (human)	Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic
14	g, h, o, p	Cytoplasmic dynein 1 intermediate chain 2	polymer	638	71546.4	4	UniProt (Q13409) Pfam (PF11540) Pfam (PF00400) In PDB	Homo sapiens (human)	Cytoplasmic dynein intermediate chain 2,Dynein intermediate chain 2,cytosolic,DH IC-2
15	i, j, q, r	Cytoplasmic dynein 1 light intermediate chain 2	polymer	492	54173.2	4	UniProt (O43237) Pfam (PF05783) In PDB	Homo sapiens (human)	Dynein light intermediate chain 2,cytosolic,LIC-2,LIC53/55
16	k, l, s, t	Dynein light chain roadblock-type 1	polymer	96	10934.6	4	UniProt (Q9NP97) Pfam (PF03259) In PDB	Homo sapiens (human)	Bithoraxoid-like protein,BLP,Dynein light chain 2A,cytoplasmic,Dynein-associated protein Km23,Roadblock domain-containing protein 1
17	F, G, n, H, I...	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	13	Chemie (ADP)
18	E, m, F, G, n...	MAGNESIUM ION	non-polymer		24.3	14	Chemie (MG)
19	n, J, e, f, m	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	5	Chemie (ATP)
20	Y	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
21	m, n, e, f	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	8	Chemie (ANP)

Sequence modifications

e, f, m, n: 1 - 4646 (UniProt: Q14204)

PDB	External Database	Details
Glu 1567	Arg 1567	conflict
Glu 1610	Lys 1610	conflict

Contents of the asymmetric unit

Polymers	Number of chains	43
	Total formula weight	4032482.4
Non-Polymers*	Number of molecules	43
	Total formula weight	12675.6
All*	Total formula weight	4045158.0

*Water molecules are not included.