7Z5M
Crystal structure of YTHDF2 with compound YLI_DC1_008
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | YTH domain-containing family protein 2 | polymer | 167 | 19367.8 | 2 | UniProt (Q9Y5A9) Pfam (PF04146) | Homo sapiens (human) | CLL-associated antigen KW-14,High-glucose-regulated protein 8,Renal carcinoma antigen NY-REN-2 |
| 2 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | F, G, K (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 4 | H, L (A, B) | ~{N},3-dimethyl-1~{H}-pyrazolo[4,3-d]pyrimidin-7-amine | non-polymer | 163.2 | 2 | Chemie (5ZK) | |||
| 5 | I, J, M, N, O... (A, B) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 6 | R, S (A, B) | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A, B: 408 - 552 (UniProt: Q9Y5A9)
| PDB | External Database | Details |
|---|---|---|
| Met 386 | - | initiating methionine |
| Gly 387 | - | expression tag |
| Ser 388 | - | expression tag |
| Ser 389 | - | expression tag |
| Tyr 390 | - | expression tag |
| His 391 | - | expression tag |
| His 392 | - | expression tag |
| His 393 | - | expression tag |
| His 394 | - | expression tag |
| His 395 | - | expression tag |
| His 396 | - | expression tag |
| Ser 397 | - | expression tag |
| Ser 398 | - | expression tag |
| Gly 399 | - | expression tag |
| Glu 400 | - | expression tag |
| Asn 401 | - | expression tag |
| Leu 402 | - | expression tag |
| Tyr 403 | - | expression tag |
| Phe 404 | - | expression tag |
| Gln 405 | - | expression tag |
| His 406 | - | expression tag |
| Met 407 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38735.7 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1365.6 | |
| All* | Total formula weight | 40101.3 |
