7Z39
Structure of Belumosudil bound to CK2alpha
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Casein kinase II subunit alpha | polymer | 328 | 39031.4 | 1 | UniProt (P68400) Pfam (PF00069) | Homo sapiens (human) | CK II alpha |
| 2 | B, D, E, F (A) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 3 | C (A) | 2-[3-[4-(1~{H}-indazol-5-ylamino)quinazolin-2-yl]phenoxy]-~{N}-propan-2-yl-ethanamide | non-polymer | 452.5 | 1 | Chemie (ICQ) | |||
| 4 | G (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | H (A) | water | water | 18.0 | 273 | Chemie (HOH) |
Sequence modifications
A: 2 - 329 (UniProt: P68400)
| PDB | External Database | Details |
|---|---|---|
| Ser 21 | Arg 21 | engineered mutation |
| Ala 74 | Lys 74 | engineered mutation |
| Ala 75 | Lys 75 | engineered mutation |
| Ala 76 | Lys 76 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39031.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 783.7 | |
| All* | Total formula weight | 39815.0 |
