7Z37

Structure of the RAF1-HSP90-CDC37 complex (RHC-II)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	AP1, BP1	Heat shock protein HSP 90-beta	polymer	732	84371.3	2	UniProt (P08238) Pfam (PF13589) Pfam (PF00183) In PDB	Homo sapiens (human)	HSP 90,Heat shock 84 kDa,HSP 84,HSP84
2	CP1	RAF proto-oncogene serine/threonine-protein kinase	polymer	659	74410.0	1	UniProt (P04049) Pfam (PF02196) Pfam (PF00130) Pfam (PF00069) In PDB	Homo sapiens (human)	Proto-oncogene c-RAF,cRaf,Raf-1
3	DP1	Hsp90 co-chaperone Cdc37	polymer	394	46535.5	1	UniProt (Q16543) Pfam (PF03234) Pfam (PF08565) Pfam (PF08564) In PDB	Homo sapiens (human)	Hsp90 chaperone protein kinase-targeting subunit,p50Cdc37
4	AP1, BP1	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)

Sequence modifications

AP1, BP1: 3 - 724 (UniProt: P08238)

PDB	External Database	Details
Met -7	-	initiating methionine
Tyr -6	-	expression tag
Pro -5	-	expression tag
Tyr -4	-	expression tag
Asp -3	-	expression tag
Val -2	-	expression tag
Pro -1	-	expression tag
Asp 0	-	expression tag
Tyr 1	-	expression tag
Ala 2	-	expression tag

CP1: 1 - 648 (UniProt: P04049)

PDB	External Database	Details
Val 419	Ile 419	conflict
Ile 420	Val 420	conflict
Gly 649	-	expression tag
Ser 650	-	expression tag
Ala 651	-	expression tag
Trp 652	-	expression tag
Ser 653	-	expression tag
His 654	-	expression tag
Pro 655	-	expression tag
Gln 656	-	expression tag
Phe 657	-	expression tag
Glu 658	-	expression tag
Lys 659	-	expression tag

DP1: 1 - 378 (UniProt: Q16543)

PDB	External Database	Details
Thr 379	-	expression tag
Arg 380	-	expression tag
Thr 381	-	expression tag
Arg 382	-	expression tag
Pro 383	-	expression tag
Leu 384	-	expression tag
Glu 385	-	expression tag
Gln 386	-	expression tag
Lys 387	-	expression tag
Leu 388	-	expression tag
Ile 389	-	expression tag
Ser 390	-	expression tag
Glu 391	-	expression tag
Glu 392	-	expression tag
Asp 393	-	expression tag
Leu 394	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	289688.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1014.4
All*	Total formula weight	290702.4

*Water molecules are not included.