7Z37

Structure of the RAF1-HSP90-CDC37 complex (RHC-II)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AP1	0001890	biological_process	placenta development
AP1	0003723	molecular_function	RNA binding
AP1	0003725	molecular_function	double-stranded RNA binding
AP1	0005515	molecular_function	protein binding
AP1	0005524	molecular_function	ATP binding
AP1	0005576	cellular_component	extracellular region
AP1	0005634	cellular_component	nucleus
AP1	0005654	cellular_component	nucleoplasm
AP1	0005737	cellular_component	cytoplasm
AP1	0005739	cellular_component	mitochondrion
AP1	0005829	cellular_component	cytosol
AP1	0005886	cellular_component	plasma membrane
AP1	0006457	biological_process	protein folding
AP1	0006986	biological_process	response to unfolded protein
AP1	0007004	biological_process	telomere maintenance via telomerase
AP1	0008180	cellular_component	COP9 signalosome
AP1	0009986	cellular_component	cell surface
AP1	0010033	biological_process	obsolete response to organic substance
AP1	0016020	cellular_component	membrane
AP1	0016887	molecular_function	ATP hydrolysis activity
AP1	0019062	biological_process	virion attachment to host cell
AP1	0019887	molecular_function	protein kinase regulator activity
AP1	0019900	molecular_function	kinase binding
AP1	0019901	molecular_function	protein kinase binding
AP1	0023026	molecular_function	MHC class II protein complex binding
AP1	0030235	molecular_function	nitric-oxide synthase regulator activity
AP1	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
AP1	0030911	molecular_function	TPR domain binding
AP1	0031072	molecular_function	heat shock protein binding
AP1	0031396	biological_process	regulation of protein ubiquitination
AP1	0031625	molecular_function	ubiquitin protein ligase binding
AP1	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
AP1	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
AP1	0032880	biological_process	regulation of protein localization
AP1	0032991	cellular_component	protein-containing complex
AP1	0034605	biological_process	cellular response to heat
AP1	0034751	cellular_component	aryl hydrocarbon receptor complex
AP1	0034774	cellular_component	secretory granule lumen
AP1	0042277	molecular_function	peptide binding
AP1	0042470	cellular_component	melanosome
AP1	0042802	molecular_function	identical protein binding
AP1	0042803	molecular_function	protein homodimerization activity
AP1	0042826	molecular_function	histone deacetylase binding
AP1	0043008	molecular_function	ATP-dependent protein binding
AP1	0043025	cellular_component	neuronal cell body
AP1	0043066	biological_process	negative regulation of apoptotic process
AP1	0044183	molecular_function	protein folding chaperone
AP1	0044294	cellular_component	dendritic growth cone
AP1	0044295	cellular_component	axonal growth cone
AP1	0045296	molecular_function	cadherin binding
AP1	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
AP1	0045597	biological_process	positive regulation of cell differentiation
AP1	0046983	molecular_function	protein dimerization activity
AP1	0048156	molecular_function	tau protein binding
AP1	0048471	cellular_component	perinuclear region of cytoplasm
AP1	0050821	biological_process	protein stabilization
AP1	0051082	molecular_function	unfolded protein binding
AP1	0051131	biological_process	chaperone-mediated protein complex assembly
AP1	0051726	biological_process	regulation of cell cycle
AP1	0061077	biological_process	chaperone-mediated protein folding
AP1	0070062	cellular_component	extracellular exosome
AP1	0070182	molecular_function	DNA polymerase binding
AP1	0071353	biological_process	cellular response to interleukin-4
AP1	0097435	biological_process	supramolecular fiber organization
AP1	0097718	molecular_function	disordered domain specific binding
AP1	0101031	cellular_component	protein folding chaperone complex
AP1	0120293	cellular_component	dynein axonemal particle
AP1	0140662	molecular_function	ATP-dependent protein folding chaperone
AP1	0141069	molecular_function	receptor ligand inhibitor activity
AP1	1901799	biological_process	negative regulation of proteasomal protein catabolic process
AP1	1904813	cellular_component	ficolin-1-rich granule lumen
AP1	1905323	biological_process	telomerase holoenzyme complex assembly
AP1	1990226	molecular_function	histone methyltransferase binding
AP1	1990565	cellular_component	HSP90-CDC37 chaperone complex
AP1	2000010	biological_process	positive regulation of protein localization to cell surface
BP1	0001890	biological_process	placenta development
BP1	0003723	molecular_function	RNA binding
BP1	0003725	molecular_function	double-stranded RNA binding
BP1	0005515	molecular_function	protein binding
BP1	0005524	molecular_function	ATP binding
BP1	0005576	cellular_component	extracellular region
BP1	0005634	cellular_component	nucleus
BP1	0005654	cellular_component	nucleoplasm
BP1	0005737	cellular_component	cytoplasm
BP1	0005739	cellular_component	mitochondrion
BP1	0005829	cellular_component	cytosol
BP1	0005886	cellular_component	plasma membrane
BP1	0006457	biological_process	protein folding
BP1	0006986	biological_process	response to unfolded protein
BP1	0007004	biological_process	telomere maintenance via telomerase
BP1	0008180	cellular_component	COP9 signalosome
BP1	0009986	cellular_component	cell surface
BP1	0010033	biological_process	obsolete response to organic substance
BP1	0016020	cellular_component	membrane
BP1	0016887	molecular_function	ATP hydrolysis activity
BP1	0019062	biological_process	virion attachment to host cell
BP1	0019887	molecular_function	protein kinase regulator activity
BP1	0019900	molecular_function	kinase binding
BP1	0019901	molecular_function	protein kinase binding
BP1	0023026	molecular_function	MHC class II protein complex binding
BP1	0030235	molecular_function	nitric-oxide synthase regulator activity
BP1	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
BP1	0030911	molecular_function	TPR domain binding
BP1	0031072	molecular_function	heat shock protein binding
BP1	0031396	biological_process	regulation of protein ubiquitination
BP1	0031625	molecular_function	ubiquitin protein ligase binding
BP1	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
BP1	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
BP1	0032880	biological_process	regulation of protein localization
BP1	0032991	cellular_component	protein-containing complex
BP1	0034605	biological_process	cellular response to heat
BP1	0034751	cellular_component	aryl hydrocarbon receptor complex
BP1	0034774	cellular_component	secretory granule lumen
BP1	0042277	molecular_function	peptide binding
BP1	0042470	cellular_component	melanosome
BP1	0042802	molecular_function	identical protein binding
BP1	0042803	molecular_function	protein homodimerization activity
BP1	0042826	molecular_function	histone deacetylase binding
BP1	0043008	molecular_function	ATP-dependent protein binding
BP1	0043025	cellular_component	neuronal cell body
BP1	0043066	biological_process	negative regulation of apoptotic process
BP1	0044183	molecular_function	protein folding chaperone
BP1	0044294	cellular_component	dendritic growth cone
BP1	0044295	cellular_component	axonal growth cone
BP1	0045296	molecular_function	cadherin binding
BP1	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
BP1	0045597	biological_process	positive regulation of cell differentiation
BP1	0046983	molecular_function	protein dimerization activity
BP1	0048156	molecular_function	tau protein binding
BP1	0048471	cellular_component	perinuclear region of cytoplasm
BP1	0050821	biological_process	protein stabilization
BP1	0051082	molecular_function	unfolded protein binding
BP1	0051131	biological_process	chaperone-mediated protein complex assembly
BP1	0051726	biological_process	regulation of cell cycle
BP1	0061077	biological_process	chaperone-mediated protein folding
BP1	0070062	cellular_component	extracellular exosome
BP1	0070182	molecular_function	DNA polymerase binding
BP1	0071353	biological_process	cellular response to interleukin-4
BP1	0097435	biological_process	supramolecular fiber organization
BP1	0097718	molecular_function	disordered domain specific binding
BP1	0101031	cellular_component	protein folding chaperone complex
BP1	0120293	cellular_component	dynein axonemal particle
BP1	0140662	molecular_function	ATP-dependent protein folding chaperone
BP1	0141069	molecular_function	receptor ligand inhibitor activity
BP1	1901799	biological_process	negative regulation of proteasomal protein catabolic process
BP1	1904813	cellular_component	ficolin-1-rich granule lumen
BP1	1905323	biological_process	telomerase holoenzyme complex assembly
BP1	1990226	molecular_function	histone methyltransferase binding
BP1	1990565	cellular_component	HSP90-CDC37 chaperone complex
BP1	2000010	biological_process	positive regulation of protein localization to cell surface
CP1	0000165	biological_process	MAPK cascade
CP1	0001678	biological_process	intracellular glucose homeostasis
CP1	0001934	biological_process	positive regulation of protein phosphorylation
CP1	0004672	molecular_function	protein kinase activity
CP1	0004674	molecular_function	protein serine/threonine kinase activity
CP1	0004709	molecular_function	MAP kinase kinase kinase activity
CP1	0005515	molecular_function	protein binding
CP1	0005524	molecular_function	ATP binding
CP1	0005634	cellular_component	nucleus
CP1	0005737	cellular_component	cytoplasm
CP1	0005739	cellular_component	mitochondrion
CP1	0005741	cellular_component	mitochondrial outer membrane
CP1	0005794	cellular_component	Golgi apparatus
CP1	0005829	cellular_component	cytosol
CP1	0005886	cellular_component	plasma membrane
CP1	0006468	biological_process	protein phosphorylation
CP1	0006915	biological_process	apoptotic process
CP1	0007165	biological_process	signal transduction
CP1	0007190	biological_process	activation of adenylate cyclase activity
CP1	0008285	biological_process	negative regulation of cell population proliferation
CP1	0008286	biological_process	insulin receptor signaling pathway
CP1	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
CP1	0014044	biological_process	Schwann cell development
CP1	0019899	molecular_function	enzyme binding
CP1	0030154	biological_process	cell differentiation
CP1	0030878	biological_process	thyroid gland development
CP1	0031143	cellular_component	pseudopodium
CP1	0031267	molecular_function	small GTPase binding
CP1	0031333	biological_process	negative regulation of protein-containing complex assembly
CP1	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
CP1	0035019	biological_process	somatic stem cell population maintenance
CP1	0035023	biological_process	regulation of Rho protein signal transduction
CP1	0035773	biological_process	insulin secretion involved in cellular response to glucose stimulus
CP1	0035994	biological_process	response to muscle stretch
CP1	0036211	biological_process	protein modification process
CP1	0038133	biological_process	ERBB2-ERBB3 signaling pathway
CP1	0042060	biological_process	wound healing
CP1	0042552	biological_process	myelination
CP1	0042802	molecular_function	identical protein binding
CP1	0042981	biological_process	regulation of apoptotic process
CP1	0043066	biological_process	negative regulation of apoptotic process
CP1	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
CP1	0043410	biological_process	positive regulation of MAPK cascade
CP1	0044342	biological_process	type B pancreatic cell proliferation
CP1	0045104	biological_process	intermediate filament cytoskeleton organization
CP1	0045595	biological_process	regulation of cell differentiation
CP1	0045944	biological_process	positive regulation of transcription by RNA polymerase II
CP1	0046872	molecular_function	metal ion binding
CP1	0048009	biological_process	insulin-like growth factor receptor signaling pathway
CP1	0048011	biological_process	neurotrophin TRK receptor signaling pathway
CP1	0048538	biological_process	thymus development
CP1	0060324	biological_process	face development
CP1	0060333	biological_process	type II interferon-mediated signaling pathway
CP1	0071550	biological_process	death-inducing signaling complex assembly
CP1	0106310	molecular_function	protein serine kinase activity
CP1	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
CP1	1902531	biological_process	regulation of intracellular signal transduction
CP1	2000145	biological_process	regulation of cell motility
DP1	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
DP1	0005515	molecular_function	protein binding
DP1	0005737	cellular_component	cytoplasm
DP1	0005829	cellular_component	cytosol
DP1	0006457	biological_process	protein folding
DP1	0006605	biological_process	protein targeting
DP1	0010608	biological_process	post-transcriptional regulation of gene expression
DP1	0019887	molecular_function	protein kinase regulator activity
DP1	0019900	molecular_function	kinase binding
DP1	0019901	molecular_function	protein kinase binding
DP1	0031072	molecular_function	heat shock protein binding
DP1	0050821	biological_process	protein stabilization
DP1	0051082	molecular_function	unfolded protein binding
DP1	0051087	molecular_function	protein-folding chaperone binding
DP1	0051879	molecular_function	Hsp90 protein binding
DP1	0060334	biological_process	regulation of type II interferon-mediated signaling pathway
DP1	0060338	biological_process	regulation of type I interferon-mediated signaling pathway
DP1	0070062	cellular_component	extracellular exosome
DP1	0097110	molecular_function	scaffold protein binding
DP1	0098779	biological_process	positive regulation of mitophagy in response to mitochondrial depolarization
DP1	0101031	cellular_component	protein folding chaperone complex
DP1	1990565	cellular_component	HSP90-CDC37 chaperone complex

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	21
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK

Chain	Residue	Details
CP1	ILE355-LYS375

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDMKsnNIFL

Chain	Residue	Details
CP1	ILE464-LEU476

---

site_id	PS00298
Number of Residues	10
Details	HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE

Chain	Residue	Details
AP1	TYR33-GLU42

---

site_id	PS00479
Number of Residues	46
Details	ZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HnFarktflklaf.CdiCqkfLlngfr.....CqtCgykfHehCstkvptm..C

Chain	Residue	Details
CP1	HIS139-CYS184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
DP1	MET1
AP1	LYS107
AP1	PHE133
AP1	ARG392
BP1	ASN46
BP1	LYS107
BP1	PHE133
BP1	ARG392

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylvaline; in Hsp90 co-chaperone Cdc37, N-terminally processed => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
DP1	VAL2
BP1	ASP88

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
DP1	SEP13
CP1	CYS152
CP1	CYS155
CP1	CYS165
CP1	CYS168
CP1	HIS173
CP1	CYS176
CP1	CYS184

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
DP1	LYS78
DP1	LYS154
BP1	LYS219
BP1	LYS577

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
DP1	THR118
BP1	SER226

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
DP1	SER120
BP1	SER255

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
DP1	SER377
BP1	SER261

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKA, PKC and PKB/AKT1 => ECO:0000269|PubMed:10576742, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:11756411, ECO:0000269|PubMed:15047712, ECO:0000269|PubMed:16630891, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:8349614

Chain	Residue	Details
CP1	SER259
BP1	THR297

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:8349614

Chain	Residue	Details
CP1	THR268
BP1	TYR301

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKA => ECO:0000269|PubMed:7477354

Chain	Residue	Details
CP1	THR269
AP1	TYR484
BP1	TYR305
BP1	TYR484

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK1 => ECO:0000269|PubMed:21917714, ECO:0007744|PubMed:19690332

Chain	Residue	Details
CP1	SER289
BP1	SER307

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
CP1	SER296
BP1	LYS399

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK1 => ECO:0000269|PubMed:21917714, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
CP1	SER301
AP1	LYS481
BP1	LYS435
BP1	LYS481

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PAK1, PAK2, PAK3 and PAK5 => ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:21917714

Chain	Residue	Details
CP1	SER338
BP1	SER445

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PAK1, PAK2 and PAK3 => ECO:0000269|PubMed:15849194

Chain	Residue	Details
CP1	SER339
BP1	THR479

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:16892053

Chain	Residue	Details
CP1	TYR340
CP1	TYR341

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:16093354

Chain	Residue	Details
CP1	SER471
BP1	LYS574

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:11447113

Chain	Residue	Details
CP1	THR491
BP1	CYS590

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:11447113

Chain	Residue	Details
CP1	SER494
BP1	LYS624

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8349614

Chain	Residue	Details
CP1	SER499
BP1	SER669

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5 => ECO:0000269|PubMed:21917714

Chain	Residue	Details
CP1	ARG563
BP1	SER718

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:8349614

Chain	Residue	Details
CP1	SER621
AP1	SER452
BP1	SER434
BP1	SER452

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK1 => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
CP1	SER642

---