7Z26

Crystal structure of YTHDF2 YTH domain in complex with m6A RNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	YTH domain-containing family protein 2	polymer	167	19367.8	2	UniProt (Q9Y5A9) Pfam (PF04146) In PDB	Homo sapiens (human)	CLL-associated antigen KW-14,High-glucose-regulated protein 8,Renal carcinoma antigen NY-REN-2
2	D, E	RNA (5'-R(P*(6MZ)P*CP*U)-3')	polymer	5	1600.0	2		Homo sapiens
3	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5		water	water		18.0	175	Chemie (HOH)

Sequence modifications

A, B: 408 - 552 (UniProt: Q9Y5A9)

PDB	External Database	Details
Met 386	-	initiating methionine
Gly 387	-	expression tag
Ser 388	-	expression tag
Ser 389	-	expression tag
Tyr 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
His 393	-	expression tag
His 394	-	expression tag
His 395	-	expression tag
His 396	-	expression tag
Ser 397	-	expression tag
Ser 398	-	expression tag
Gly 399	-	expression tag
Glu 400	-	expression tag
Asn 401	-	expression tag
Leu 402	-	expression tag
Tyr 403	-	expression tag
Phe 404	-	expression tag
Gln 405	-	expression tag
His 406	-	expression tag
Met 407	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	41935.8
Non-Polymers*	Number of molecules	3
	Total formula weight	284.2
All*	Total formula weight	42220.0

*Water molecules are not included.