7Z1G
Crystal structure of nonphosphorylated (Tyr216) GSK3b in complex with CX-4945
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glycogen synthase kinase-3 beta | polymer | 364 | 41504.7 | 1 | UniProt (P49841) Pfam (PF00069) | Homo sapiens (human) | GSK-3 beta,Serine/threonine-protein kinase GSK3B |
| 2 | B (A) | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid | non-polymer | 349.8 | 1 | Chemie (3NG) | |||
| 3 | C, D, E, F, G (A) | MALONATE ION | non-polymer | 102.0 | 5 | Chemie (MLI) | |||
| 4 | H, I (A) | IMIDAZOLE | non-polymer | 69.1 | 2 | Chemie (IMD) | |||
| 5 | J (A) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A: 26 - 383 (UniProt: P49841)
| PDB | External Database | Details |
|---|---|---|
| Glu 384 | - | expression tag |
| Asn 385 | - | expression tag |
| Leu 386 | - | expression tag |
| Tyr 387 | - | expression tag |
| Phe 388 | - | expression tag |
| Gln 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41504.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 998.2 | |
| All* | Total formula weight | 42502.8 |
