7YU7

Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	354	40415.0	1	UniProt (P63096) Pfam (PF00503)	Homo sapiens (human)	Adenylate cyclase-inhibiting G alpha protein
2	B (R)	Lysophosphatidic acid receptor 1	polymer	379	42936.0	1	UniProt (Q92633) Pfam (PF00001)	Homo sapiens (human)	LPA receptor 1,LPA-1,Lysophosphatidic acid receptor Edg-2
3	C (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	351	38744.4	1	UniProt (P54311) Pfam (PF00400)	Rattus norvegicus (Norway rat)	Transducin beta chain 1
4	D (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	68	7547.7	1	UniProt (P63212) Pfam (PF00631)	Bos taurus (cattle)	G gamma-I
5	E (S)	scFv16	polymer	260	27720.8	1		Mus musculus
6	F (R)	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate	non-polymer		415.5	1	Chemie (K6L)

Sequence modifications

R: 2 - 364 (UniProt: Q92633)

PDB	External Database	Details
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Ala -1	-	expression tag
Met 0	-	expression tag
Gly 1	-	expression tag
Glu 365	-	expression tag
Asn 366	-	expression tag
Leu 367	-	expression tag
Tyr 368	-	expression tag
Phe 369	-	expression tag
Gln 370	-	expression tag

B: 2 - 340 (UniProt: P54311)

PDB	External Database	Details
Met -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag

G: 1 - 67 (UniProt: P63212)

PDB	External Database	Details
Ser 68	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	157363.9
Non-Polymers*	Number of molecules	1
	Total formula weight	415.5
All*	Total formula weight	157779.3

*Water molecules are not included.