7YRG

histone methyltransferase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, G (A, E)	Histone H3.2	polymer	103	12046.1	2	UniProt (P84233) Pfam (PF00125)	Xenopus laevis (African clawed frog)
2	B, H (B, F)	Histone H4	polymer	102	11265.2	2	UniProt (P62799) Pfam (PF15511)	Xenopus laevis (African clawed frog)
3	C, D (I, J)	DNA (146-MER)	polymer	146	45054.8	2		Homo sapiens
4	E, I (C, G)	Histone H2A.Z	polymer	113	12091.1	2	UniProt (P0C0S5) Pfam (PF00125) Pfam (PF16211)	Homo sapiens (human)	H2A/z
5	F, J (D, H)	Histone H2B 1.1	polymer	95	10607.2	2	UniProt (P02281) Pfam (PF00125)	Xenopus laevis (African clawed frog)	H2B1.1
6	K, L (K, L)	[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B	polymer	279	32214.8	2	UniProt (B7WNX0) Pfam (PF00856) UniProt (by SIFTS) (Q4FZB7)	Homo sapiens (human)	[histone H4]-lysine20 N-methyltransferase KMT5B
7	M, O (K, L)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
8	N, P (K, L)	S-ADENOSYLMETHIONINE	non-polymer		398.4	2	Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (58766358) PubChem (73897310) PubChem (9865603) PubChem (87224684) PubChem (12312798) PubChem (131697735) PubChem (145712080) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094)

Sequence modifications

A, E: 33 - 135 (UniProt: P84233)

PDB	External Database	Details
Glu 34	Gly 35	engineered mutation
Ala 102	Gly 103	engineered mutation

B, F: 1 - 102 (UniProt: P62799)

PDB	External Database	Details
Ecx 20	Lys 21	modified residue

D, H: 31 - 125 (UniProt: P02281)

PDB	External Database	Details
Thr 32	Ser 33	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	246558.5
Non-Polymers*	Number of molecules	4
	Total formula weight	927.7
All*	Total formula weight	247486.2

*Water molecules are not included.