7YRG

histone methyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0030527	molecular_function	structural constituent of chromatin
E	0046982	molecular_function	protein heterodimerization activity
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
K	0042799	molecular_function	histone H4K20 methyltransferase activity
L	0042799	molecular_function	histone H4K20 methyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA23-VAL29

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site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

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site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG92-GLY114

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site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273, ECO:0000269|Ref.14, ECO:0007744|PDB:3S8P, ECO:0007744|PDB:5CPR, ECO:0007744|PDB:5WBV

Chain	Residue	Details
K	HIS98
L	HIS98
L	LEU226
L	GLU233
L	ARG295
L	GLU298
L	ALA342
L	PRO343
L	VAL344
L	SER347
K	LEU226
K	GLU233
K	ARG295
K	GLU298
K	ALA342
K	PRO343
K	VAL344
K	SER347

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273, ECO:0007744|PDB:3S8P, ECO:0007744|PDB:5CPR

Chain	Residue	Details
K	LYS280
L	LYS280
H	LYS120

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:11835281

Chain	Residue	Details
C	LYS121
F	ARG3
G	LYS121

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-lactoyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS5
F	LYS5
E	LYS56
E	LYS79

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS8
B	LYS16
B	LYS44
B	LYS79
F	LYS8
F	LYS16
F	LYS44
F	LYS79

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS12
B	ECX20
F	LYS12
F	ECX20

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS31
B	LYS91
F	LYS31
F	LYS91

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PAK2 => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	SER47
F	SER47

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	TYR51
B	TYR88
F	TYR51
F	TYR88

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS59
F	LYS59

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS77
F	LYS77

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS31
F	LYS31

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
B	LYS91
F	LYS91

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