7YQ4
human insulin receptor bound with A62 DNA aptamer and insulin - locally refined
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (E, F) | Isoform Short of Insulin receptor | polymer | 907 | 103623.6 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) | Homo sapiens (human) | |
| 2 | B (B) | Insulin, isoform 2 | polymer | 25 | 2860.3 | 1 | UniProt (F8WCM5) | Homo sapiens (human) | INS-IGF2 readthrough transcript protein |
| 3 | C (A) | Insulin A chain | polymer | 21 | 2383.7 | 1 | UniProt (P01308) | Homo sapiens (human) | Small chain |
| 4 | E (G) | IR-A62 aptamer | polymer | 24 | 8526.8 | 1 | synthetic construct |
Sequence modifications
E, F: 1 - 907 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | conflict |
| Thr 421 | Ile 448 | conflict |
| Lys 465 | Gln 492 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 221017.9 | |
| All* | Total formula weight | 221017.9 |
