7YON
Complex structure of Neuropeptide Y Y2 receptor in complex with PYY(3-36) and Gi
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (L) | Peptide YY(3-36) | polymer | 34 | 4055.5 | 1 | UniProt (P10082) Pfam (PF00159) | Homo sapiens | PYY-II |
| 5 | E (R) | Neuropeptide Y receptor type 2 | polymer | 391 | 43783.1 | 1 | UniProt (P49146) Pfam (PF00001) | Homo sapiens (human) | NPY2-R,NPY-Y2 receptor,Y2 receptor |
| 6 | F (S) | single-chain antibody Fv fragment (scFv16) | polymer | 259 | 27784.9 | 1 | Mus musculus | ||
| 7 | G, H (L, R) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
L: 3 - 36 (UniProt: P10082)
R: 2 - 381 (UniProt: P49146)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 9 | Arg 37 | variant |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Tyr 149 | His 149 | engineered mutation |
| Cys 280 | Ser 280 | engineered mutation |
| Ala 382 | - | expression tag |
| Ser 383 | - | expression tag |
| Gly 384 | - | expression tag |
| Leu 385 | - | expression tag |
| Glu 386 | - | expression tag |
| Val 387 | - | expression tag |
| Leu 388 | - | expression tag |
| Phe 389 | - | expression tag |
| Gln 390 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 161627.8 | |
| All* | Total formula weight | 161627.8 |
