7YI7
Crystal structure of Human HPSE1 in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Heparanase 50 kDa subunit | polymer | 386 | 43464.1 | 1 | UniProt (Q9Y251) Pfam (PF03662) In PDB | Homo sapiens (human) | |
| 2 | B | Heparanase 8 kDa subunit | polymer | 74 | 8273.5 | 1 | UniProt (Q9Y251) In PDB | Homo sapiens (human) | |
| 3 | A | (5~{S},6~{R},7~{S},8~{S})-6,7,8-tris(oxidanyl)-2-[2-[4-(trifluoromethyl)phenyl]ethyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid | non-polymer | 386.3 | 1 | Chemie (IUV) | |||
| 4 | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A: 158 - 543 (UniProt: Q9Y251)
| PDB | External Database | Details |
|---|---|---|
| Arg 307 | Lys 307 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51737.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 386.3 | |
| All* | Total formula weight | 52123.9 |
