7YG1

Cryo-EM structure of the C-terminal domain of the human sodium-chloride cotransporter

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Solute carrier family 12 member 3	polymer	1053	116921.5	2	UniProt (P55017) Pfam (PF08403) Pfam (PF00324) Pfam (PF03522)	Homo sapiens (human)	Na-Cl cotransporter, cation-chloride cotransporter

Sequence modifications

A, B: 2 - 1021 (UniProt: P55017)

PDB	External Database	Details
-	Gln 95	deletion
Gly 264	Ala 264	engineered mutation
Leu 1022	-	expression tag
Glu 1023	-	expression tag
Gly 1024	-	expression tag
Ser 1025	-	expression tag
Asp 1026	-	expression tag
Glu 1027	-	expression tag
Val 1028	-	expression tag
Asp 1029	-	expression tag
Ala 1030	-	expression tag
Gly 1031	-	expression tag
Ser 1032	-	expression tag
His 1033	-	expression tag
His 1034	-	expression tag
His 1035	-	expression tag
His 1036	-	expression tag
His 1037	-	expression tag
His 1038	-	expression tag
His 1039	-	expression tag
His 1040	-	expression tag
His 1041	-	expression tag
His 1042	-	expression tag
Gly 1043	-	expression tag
Ser 1044	-	expression tag
Val 1045	-	expression tag
Glu 1046	-	expression tag
Asp 1047	-	expression tag
Tyr 1048	-	expression tag
Lys 1049	-	expression tag
Asp 1050	-	expression tag
Asp 1051	-	expression tag
Asp 1052	-	expression tag
Asp 1053	-	expression tag
Lys 1054	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	233842.9
All*	Total formula weight	233842.9

*Water molecules are not included.