7YG1

Cryo-EM structure of the C-terminal domain of the human sodium-chloride cotransporter

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0006884	biological_process	cell volume homeostasis
A	0008511	molecular_function	sodium:potassium:chloride symporter activity
A	0015081	molecular_function	sodium ion transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015377	molecular_function	chloride:monoatomic cation symporter activity
A	0015378	molecular_function	sodium:chloride symporter activity
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0035725	biological_process	sodium ion transmembrane transport
A	0055064	biological_process	chloride ion homeostasis
A	0055075	biological_process	potassium ion homeostasis
A	0055078	biological_process	sodium ion homeostasis
A	0055085	biological_process	transmembrane transport
A	0070062	cellular_component	extracellular exosome
A	0070294	biological_process	renal sodium ion absorption
A	1902074	biological_process	response to salt
A	1902476	biological_process	chloride transmembrane transport
A	1904044	biological_process	response to aldosterone
A	1990573	biological_process	potassium ion import across plasma membrane
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0006884	biological_process	cell volume homeostasis
B	0008511	molecular_function	sodium:potassium:chloride symporter activity
B	0015081	molecular_function	sodium ion transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015377	molecular_function	chloride:monoatomic cation symporter activity
B	0015378	molecular_function	sodium:chloride symporter activity
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0035725	biological_process	sodium ion transmembrane transport
B	0055064	biological_process	chloride ion homeostasis
B	0055075	biological_process	potassium ion homeostasis
B	0055078	biological_process	sodium ion homeostasis
B	0055085	biological_process	transmembrane transport
B	0070062	cellular_component	extracellular exosome
B	0070294	biological_process	renal sodium ion absorption
B	1902074	biological_process	response to salt
B	1902476	biological_process	chloride transmembrane transport
B	1904044	biological_process	response to aldosterone
B	1990573	biological_process	potassium ion import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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