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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7YFC

Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Engineered G-alpha-qpolymer36141724.41Pfam (PF00503)
UniProt (by SIFTS) (P63096)
UniProt (by SIFTS) (P63092)		Homo sapiens
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer38842282.21UniProt (P62873)
Pfam (PF00400)		Homo sapiens (human)Transducin beta chain 1
3C
(C)		scFv16polymer25927784.91Mus musculus
4D
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
5E
(N)		Nb35polymer12914016.61Lama glama
6F
(R)		Histamine H4 receptorpolymer54862137.71UniProt (Q9H3N8)
Pfam (PF00001)		Homo sapiens (human)H4R,HH4R,AXOR35,G-protein coupled receptor 105,GPRv53,Pfi-013,SP9144
7G
(R)		HISTAMINEnon-polymer111.11Chemie (HSM)
8H
(R)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -21-initiating methionine
His -20-expression tag
His -19-expression tag
His -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
Leu -10-expression tag
Glu -9-expression tag
Val -8-expression tag
Leu -7-expression tag
Phe -6-expression tag
Gln -5-expression tag
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
R: 1 - 390 (UniProt: Q9H3N8)
PDBExternal DatabaseDetails
Val 391-expression tag
Phe 392-expression tag
Thr 393-expression tag
Leu 394-expression tag
Glu 395-expression tag
Asp 396-expression tag
Phe 397-expression tag
Val 398-expression tag
Gly 399-expression tag
Asp 400-expression tag
Trp 401-expression tag
Glu 402-expression tag
Gln 403-expression tag
Thr 404-expression tag
Ala 405-expression tag
Ala 406-expression tag
Tyr 407-expression tag
Asn 408-expression tag
Leu 409-expression tag
Asp 410-expression tag
Gln 411-expression tag
Val 412-expression tag
Leu 413-expression tag
Glu 414-expression tag
Gln 415-expression tag
Gly 416-expression tag
Gly 417-expression tag
Val 418-expression tag
Ser 419-expression tag
Ser 420-expression tag
Leu 421-expression tag
Leu 422-expression tag
Gln 423-expression tag
Asn 424-expression tag
Leu 425-expression tag
Ala 426-expression tag
Val 427-expression tag
Ser 428-expression tag
Val 429-expression tag
Thr 430-expression tag
Pro 431-expression tag
Ile 432-expression tag
Gln 433-expression tag
Arg 434-expression tag
Ile 435-expression tag
Val 436-expression tag
Arg 437-expression tag
Ser 438-expression tag
Gly 439-expression tag
Glu 440-expression tag
Asn 441-expression tag
Ala 442-expression tag
Leu 443-expression tag
Lys 444-expression tag
Ile 445-expression tag
Asp 446-expression tag
Ile 447-expression tag
His 448-expression tag
Val 449-expression tag
Ile 450-expression tag
Ile 451-expression tag
Pro 452-expression tag
Tyr 453-expression tag
Glu 454-expression tag
Gly 455-expression tag
Leu 456-expression tag
Ser 457-expression tag
Ala 458-expression tag
Asp 459-expression tag
Gln 460-expression tag
Met 461-expression tag
Ala 462-expression tag
Gln 463-expression tag
Ile 464-expression tag
Glu 465-expression tag
Glu 466-expression tag
Val 467-expression tag
Phe 468-expression tag
Lys 469-expression tag
Val 470-expression tag
Val 471-expression tag
Tyr 472-expression tag
Pro 473-expression tag
Val 474-expression tag
Asp 475-expression tag
Asp 476-expression tag
His 477-expression tag
His 478-expression tag
Phe 479-expression tag
Lys 480-expression tag
Val 481-expression tag
Ile 482-expression tag
Leu 483-expression tag
Pro 484-expression tag
Tyr 485-expression tag
Gly 486-expression tag
Thr 487-expression tag
Leu 488-expression tag
Val 489-expression tag
Ile 490-expression tag
Asp 491-expression tag
Gly 492-expression tag
Val 493-expression tag
Thr 494-expression tag
Pro 495-expression tag
Asn 496-expression tag
Met 497-expression tag
Leu 498-expression tag
Asn 499-expression tag
Tyr 500-expression tag
Phe 501-expression tag
Gly 502-expression tag
Arg 503-expression tag
Pro 504-expression tag
Tyr 505-expression tag
Glu 506-expression tag
Gly 507-expression tag
Ile 508-expression tag
Ala 509-expression tag
Val 510-expression tag
Phe 511-expression tag
Asp 512-expression tag
Gly 513-expression tag
Lys 514-expression tag
Lys 515-expression tag
Ile 516-expression tag
Thr 517-expression tag
Val 518-expression tag
Thr 519-expression tag
Gly 520-expression tag
Thr 521-expression tag
Leu 522-expression tag
Trp 523-expression tag
Asn 524-expression tag
Gly 525-expression tag
Asn 526-expression tag
Lys 527-expression tag
Ile 528-expression tag
Ile 529-expression tag
Asp 530-expression tag
Glu 531-expression tag
Arg 532-expression tag
Leu 533-expression tag
Ile 534-expression tag
Thr 535-expression tag
Pro 536-expression tag
Asp 537-expression tag
Gly 538-expression tag
Ser 539-expression tag
Met 540-expression tag
Leu 541-expression tag
Phe 542-expression tag
Arg 543-expression tag
Val 544-expression tag
Thr 545-expression tag
Ile 546-expression tag
Asn 547-expression tag
Ser 548-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight195806.9
Non-Polymers*Number of molecules2
Total formula weight497.8
All*Total formula weight196304.7
*Water molecules are not included.

246704

PDB entries from 2025-12-24

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