7YC9
Co-crystal structure of BTK kinase domain with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase BTK | polymer | 269 | 31352.0 | 1 | UniProt (Q06187) Pfam (PF07714) In PDB | Homo sapiens (human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | A | (7~{S})-2-(4-bromanyl-3,5-dimethoxy-phenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | non-polymer | 520.4 | 1 | Chemie (IS4) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 332 | Chemie (HOH) |
Sequence modifications
A: 393 - 659 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 391 | - | expression tag |
| Ser 392 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31352.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 582.5 | |
| All* | Total formula weight | 31934.5 |
