7YBR
Crystal structure of human transthyretin variant A97S complexed with Tolcapone
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Transthyretin | polymer | 136 | 14995.7 | 2 | UniProt (P02766) Pfam (PF00576) In PDB | Homo sapiens (human) | ATTR,Prealbumin,TBPA |
2 | A, B | Tolcapone | non-polymer | 273.2 | 2 | Chemie (TCW) | |||
3 | water | water | 18.0 | 141 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 127 (UniProt: P02766)
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
Ser 97 | Ala 117 | engineered mutation |
Leu 128 | - | expression tag |
Glu 129 | - | expression tag |
His 130 | - | expression tag |
His 131 | - | expression tag |
His 132 | - | expression tag |
His 133 | - | expression tag |
His 134 | - | expression tag |
His 135 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 29991.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 546.5 | |
All* | Total formula weight | 30537.9 |