7Y9C

Crystal structure of METTL9 in complex with SLC39A5 peptide and SAH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Protein-L-histidine N-pros-methyltransferase	polymer	275	31554.0	2	UniProt (Q9H1A3) Pfam (PF05219)	Homo sapiens (human)	DORA reverse strand protein,DREV,DREV1,Methyltransferase-like protein 9,hMETTL9, METTL9
2	C, D (C, D)	SLC39A5	polymer	13	1375.4	2	UniProt (by SIFTS) (Q6ZMH5)	synthetic construct
3	E, F (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
4	G, H, I, J (A, B, C, D)	water	water		18.0	394	Chemie (HOH)

Sequence modifications

A, B: 46 - 318 (UniProt: Q9H1A3)

PDB	External Database	Details
His 44	-	expression tag
Met 45	-	expression tag
Ala 95	Leu 95	engineered mutation
Ala 96	Phe 96	engineered mutation
Ala 99	Leu 99	engineered mutation
Ala 103	Phe 103	engineered mutation
Ala 107	Val 107	engineered mutation
Ala 111	Phe 111	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	65858.8
Non-Polymers*	Number of molecules	2
	Total formula weight	768.8
All*	Total formula weight	66627.6

*Water molecules are not included.