7Y6K
Cryo-EM structure of SARS-CoV-2 receptor binding domain in complex with K202.B bispecific antibody
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Spike glycoprotein | polymer | 1208 | 133781.3 | 1 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
2 | E, I | scFv region of light chain from K202.B, bispecific antibody | polymer | 478 | 49646.2 | 2 | Homo sapiens | ||
3 | J | Fab region of heavy chain from K202.B, bispecific antibody | polymer | 454 | 49846.8 | 1 | Homo sapiens | ||
4 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
B: 1 - 1208 (UniProt: P0DTC2)
PDB | External Database | Details |
---|---|---|
Gly 682 | Arg 682 | engineered mutation |
Ser 683 | Arg 683 | engineered mutation |
Ser 685 | Arg 685 | engineered mutation |
Pro 817 | Phe 817 | engineered mutation |
Pro 892 | Ala 892 | engineered mutation |
Pro 899 | Ala 899 | engineered mutation |
Pro 942 | Ala 942 | engineered mutation |
Pro 986 | Lys 986 | engineered mutation |
Pro 987 | Val 987 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 282920.5 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 221.2 | |
All* | Total formula weight | 283141.7 |