7Y53
The cryo-EM structure of human ERAD retro-translocation complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (W, X, Y, Z) | Derlin-1 | polymer | 226 | 26478.1 | 4 | UniProt (Q9BUN8) Pfam (PF04511) | Homo sapiens (human) | Degradation in endoplasmic reticulum protein 1,DERtrin-1,Der1-like protein 1 |
| 2 | E, F, G, H, I... (A, B, C, D, E...) | Transitional endoplasmic reticulum ATPase | polymer | 787 | 87546.7 | 6 | UniProt (P55072) Pfam (PF02359) Pfam (PF02933) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (human) | TER ATPase,15S Mg(2+)-ATPase p97 subunit,Valosin-containing protein,VCP |
| 3 | K, L, M, N, O... (A, B, C, D, E...) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 12 | Chemie (ADP) |
Sequence modifications
W, X, Y, Z: 1 - 251 (UniProt: Q9BUN8)
A, B, C, D, E, F: 21 - 806 (UniProt: P55072)
| PDB | External Database | Details |
|---|---|---|
| - | Arg 214 | deletion |
| - | Gly 215 | deletion |
| - | Gly 216 | deletion |
| - | Val 217 | deletion |
| - | Ser 218 | deletion |
| - | Gly 219 | deletion |
| - | Phe 220 | deletion |
| - | Gly 221 | deletion |
| - | Val 222 | deletion |
| - | Pro 223 | deletion |
| - | Pro 224 | deletion |
| - | Ala 225 | deletion |
| - | Ser 226 | deletion |
| - | Met 227 | deletion |
| - | Arg 228 | deletion |
| - | Arg 229 | deletion |
| - | Ala 230 | deletion |
| - | Ala 231 | deletion |
| - | Asp 232 | deletion |
| - | Gln 233 | deletion |
| - | Asn 234 | deletion |
| - | Gly 235 | deletion |
| - | Gly 236 | deletion |
| - | Gly 237 | deletion |
| - | Gly 238 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Met 20 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 631192.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 5126.4 | |
| All* | Total formula weight | 636319.1 |
