7Y53

The cryo-EM structure of human ERAD retro-translocation complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0003689	molecular_function	DNA clamp loader activity
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006302	biological_process	double-strand break repair
A	0006338	biological_process	chromatin remodeling
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006734	biological_process	NADH metabolic process
A	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
A	0006914	biological_process	autophagy
A	0006974	biological_process	DNA damage response
A	0008289	molecular_function	lipid binding
A	0010494	cellular_component	cytoplasmic stress granule
A	0010498	biological_process	proteasomal protein catabolic process
A	0010918	biological_process	positive regulation of mitochondrial membrane potential
A	0016236	biological_process	macroautophagy
A	0016567	biological_process	protein ubiquitination
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0019079	biological_process	viral genome replication
A	0019903	molecular_function	protein phosphatase binding
A	0019904	molecular_function	protein domain specific binding
A	0019985	biological_process	translesion synthesis
A	0030968	biological_process	endoplasmic reticulum unfolded protein response
A	0030970	biological_process	retrograde protein transport, ER to cytosol
A	0031334	biological_process	positive regulation of protein-containing complex assembly
A	0031593	molecular_function	polyubiquitin modification-dependent protein binding
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
A	0032991	cellular_component	protein-containing complex
A	0033554	biological_process	cellular response to stress
A	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
A	0034605	biological_process	cellular response to heat
A	0034774	cellular_component	secretory granule lumen
A	0035331	biological_process	negative regulation of hippo signaling
A	0035578	cellular_component	azurophil granule lumen
A	0035617	biological_process	stress granule disassembly
A	0035800	molecular_function	deubiquitinase activator activity
A	0035861	cellular_component	site of double-strand break
A	0036297	biological_process	interstrand cross-link repair
A	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
A	0036503	biological_process	ERAD pathway
A	0036513	cellular_component	Derlin-1 retrotranslocation complex
A	0042288	molecular_function	MHC class I protein binding
A	0042802	molecular_function	identical protein binding
A	0042981	biological_process	regulation of apoptotic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043531	molecular_function	ADP binding
A	0044389	molecular_function	ubiquitin-like protein ligase binding
A	0044877	molecular_function	protein-containing complex binding
A	0045184	biological_process	establishment of protein localization
A	0045202	cellular_component	synapse
A	0045732	biological_process	positive regulation of protein catabolic process
A	0045879	biological_process	negative regulation of smoothened signaling pathway
A	0046034	biological_process	ATP metabolic process
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050807	biological_process	regulation of synapse organization
A	0051228	biological_process	mitotic spindle disassembly
A	0061775	molecular_function	cohesin loader activity
A	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
A	0070062	cellular_component	extracellular exosome
A	0070842	biological_process	aggresome assembly
A	0071218	biological_process	cellular response to misfolded protein
A	0072389	biological_process	flavin adenine dinucleotide catabolic process
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
A	0097352	biological_process	autophagosome maturation
A	0098978	cellular_component	glutamatergic synapse
A	0106300	biological_process	protein-DNA covalent cross-linking repair
A	0120186	biological_process	negative regulation of protein localization to chromatin
A	0140036	molecular_function	ubiquitin-modified protein reader activity
A	0140455	biological_process	cytoplasm protein quality control
A	0140584	molecular_function	chromatin extrusion motor activity
A	0140588	biological_process	chromatin looping
A	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
A	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
A	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
A	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
A	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
A	1903715	biological_process	regulation of aerobic respiration
A	1903843	biological_process	cellular response to arsenite ion
A	1903862	biological_process	positive regulation of oxidative phosphorylation
A	1904288	molecular_function	BAT3 complex binding
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	1904949	cellular_component	ATPase complex
A	1905634	biological_process	regulation of protein localization to chromatin
A	1990381	molecular_function	ubiquitin-specific protease binding
A	1990730	cellular_component	VCP-NSFL1C complex
A	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
A	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
A	2001171	biological_process	positive regulation of ATP biosynthetic process
B	0000502	cellular_component	proteasome complex
B	0003689	molecular_function	DNA clamp loader activity
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006302	biological_process	double-strand break repair
B	0006338	biological_process	chromatin remodeling
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006734	biological_process	NADH metabolic process
B	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
B	0006914	biological_process	autophagy
B	0006974	biological_process	DNA damage response
B	0008289	molecular_function	lipid binding
B	0010494	cellular_component	cytoplasmic stress granule
B	0010498	biological_process	proteasomal protein catabolic process
B	0010918	biological_process	positive regulation of mitochondrial membrane potential
B	0016236	biological_process	macroautophagy
B	0016567	biological_process	protein ubiquitination
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0019079	biological_process	viral genome replication
B	0019903	molecular_function	protein phosphatase binding
B	0019904	molecular_function	protein domain specific binding
B	0019985	biological_process	translesion synthesis
B	0030968	biological_process	endoplasmic reticulum unfolded protein response
B	0030970	biological_process	retrograde protein transport, ER to cytosol
B	0031334	biological_process	positive regulation of protein-containing complex assembly
B	0031593	molecular_function	polyubiquitin modification-dependent protein binding
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
B	0032991	cellular_component	protein-containing complex
B	0033554	biological_process	cellular response to stress
B	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
B	0034605	biological_process	cellular response to heat
B	0034774	cellular_component	secretory granule lumen
B	0035331	biological_process	negative regulation of hippo signaling
B	0035578	cellular_component	azurophil granule lumen
B	0035617	biological_process	stress granule disassembly
B	0035800	molecular_function	deubiquitinase activator activity
B	0035861	cellular_component	site of double-strand break
B	0036297	biological_process	interstrand cross-link repair
B	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
B	0036503	biological_process	ERAD pathway
B	0036513	cellular_component	Derlin-1 retrotranslocation complex
B	0042288	molecular_function	MHC class I protein binding
B	0042802	molecular_function	identical protein binding
B	0042981	biological_process	regulation of apoptotic process
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0043531	molecular_function	ADP binding
B	0044389	molecular_function	ubiquitin-like protein ligase binding
B	0044877	molecular_function	protein-containing complex binding
B	0045184	biological_process	establishment of protein localization
B	0045202	cellular_component	synapse
B	0045732	biological_process	positive regulation of protein catabolic process
B	0045879	biological_process	negative regulation of smoothened signaling pathway
B	0046034	biological_process	ATP metabolic process
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050807	biological_process	regulation of synapse organization
B	0051228	biological_process	mitotic spindle disassembly
B	0061775	molecular_function	cohesin loader activity
B	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
B	0070062	cellular_component	extracellular exosome
B	0070842	biological_process	aggresome assembly
B	0071218	biological_process	cellular response to misfolded protein
B	0072389	biological_process	flavin adenine dinucleotide catabolic process
B	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
B	0097352	biological_process	autophagosome maturation
B	0098978	cellular_component	glutamatergic synapse
B	0106300	biological_process	protein-DNA covalent cross-linking repair
B	0120186	biological_process	negative regulation of protein localization to chromatin
B	0140036	molecular_function	ubiquitin-modified protein reader activity
B	0140455	biological_process	cytoplasm protein quality control
B	0140584	molecular_function	chromatin extrusion motor activity
B	0140588	biological_process	chromatin looping
B	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
B	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
B	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
B	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
B	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
B	1903715	biological_process	regulation of aerobic respiration
B	1903843	biological_process	cellular response to arsenite ion
B	1903862	biological_process	positive regulation of oxidative phosphorylation
B	1904288	molecular_function	BAT3 complex binding
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	1904949	cellular_component	ATPase complex
B	1905634	biological_process	regulation of protein localization to chromatin
B	1990381	molecular_function	ubiquitin-specific protease binding
B	1990730	cellular_component	VCP-NSFL1C complex
B	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
B	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
B	2001171	biological_process	positive regulation of ATP biosynthetic process
C	0000502	cellular_component	proteasome complex
C	0003689	molecular_function	DNA clamp loader activity
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005811	cellular_component	lipid droplet
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006302	biological_process	double-strand break repair
C	0006338	biological_process	chromatin remodeling
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006734	biological_process	NADH metabolic process
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006914	biological_process	autophagy
C	0006974	biological_process	DNA damage response
C	0008289	molecular_function	lipid binding
C	0010494	cellular_component	cytoplasmic stress granule
C	0010498	biological_process	proteasomal protein catabolic process
C	0010918	biological_process	positive regulation of mitochondrial membrane potential
C	0016236	biological_process	macroautophagy
C	0016567	biological_process	protein ubiquitination
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0019079	biological_process	viral genome replication
C	0019903	molecular_function	protein phosphatase binding
C	0019904	molecular_function	protein domain specific binding
C	0019985	biological_process	translesion synthesis
C	0030968	biological_process	endoplasmic reticulum unfolded protein response
C	0030970	biological_process	retrograde protein transport, ER to cytosol
C	0031334	biological_process	positive regulation of protein-containing complex assembly
C	0031593	molecular_function	polyubiquitin modification-dependent protein binding
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
C	0032991	cellular_component	protein-containing complex
C	0033554	biological_process	cellular response to stress
C	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
C	0034605	biological_process	cellular response to heat
C	0034774	cellular_component	secretory granule lumen
C	0035331	biological_process	negative regulation of hippo signaling
C	0035578	cellular_component	azurophil granule lumen
C	0035617	biological_process	stress granule disassembly
C	0035800	molecular_function	deubiquitinase activator activity
C	0035861	cellular_component	site of double-strand break
C	0036297	biological_process	interstrand cross-link repair
C	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
C	0036503	biological_process	ERAD pathway
C	0036513	cellular_component	Derlin-1 retrotranslocation complex
C	0042288	molecular_function	MHC class I protein binding
C	0042802	molecular_function	identical protein binding
C	0042981	biological_process	regulation of apoptotic process
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0043531	molecular_function	ADP binding
C	0044389	molecular_function	ubiquitin-like protein ligase binding
C	0044877	molecular_function	protein-containing complex binding
C	0045184	biological_process	establishment of protein localization
C	0045202	cellular_component	synapse
C	0045732	biological_process	positive regulation of protein catabolic process
C	0045879	biological_process	negative regulation of smoothened signaling pathway
C	0046034	biological_process	ATP metabolic process
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050807	biological_process	regulation of synapse organization
C	0051228	biological_process	mitotic spindle disassembly
C	0061775	molecular_function	cohesin loader activity
C	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
C	0070062	cellular_component	extracellular exosome
C	0070842	biological_process	aggresome assembly
C	0071218	biological_process	cellular response to misfolded protein
C	0072389	biological_process	flavin adenine dinucleotide catabolic process
C	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
C	0097352	biological_process	autophagosome maturation
C	0098978	cellular_component	glutamatergic synapse
C	0106300	biological_process	protein-DNA covalent cross-linking repair
C	0120186	biological_process	negative regulation of protein localization to chromatin
C	0140036	molecular_function	ubiquitin-modified protein reader activity
C	0140455	biological_process	cytoplasm protein quality control
C	0140584	molecular_function	chromatin extrusion motor activity
C	0140588	biological_process	chromatin looping
C	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
C	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
C	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
C	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
C	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
C	1903715	biological_process	regulation of aerobic respiration
C	1903843	biological_process	cellular response to arsenite ion
C	1903862	biological_process	positive regulation of oxidative phosphorylation
C	1904288	molecular_function	BAT3 complex binding
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	1904949	cellular_component	ATPase complex
C	1905634	biological_process	regulation of protein localization to chromatin
C	1990381	molecular_function	ubiquitin-specific protease binding
C	1990730	cellular_component	VCP-NSFL1C complex
C	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
C	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
C	2001171	biological_process	positive regulation of ATP biosynthetic process
D	0000502	cellular_component	proteasome complex
D	0003689	molecular_function	DNA clamp loader activity
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005811	cellular_component	lipid droplet
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006302	biological_process	double-strand break repair
D	0006338	biological_process	chromatin remodeling
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006734	biological_process	NADH metabolic process
D	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
D	0006914	biological_process	autophagy
D	0006974	biological_process	DNA damage response
D	0008289	molecular_function	lipid binding
D	0010494	cellular_component	cytoplasmic stress granule
D	0010498	biological_process	proteasomal protein catabolic process
D	0010918	biological_process	positive regulation of mitochondrial membrane potential
D	0016236	biological_process	macroautophagy
D	0016567	biological_process	protein ubiquitination
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0019079	biological_process	viral genome replication
D	0019903	molecular_function	protein phosphatase binding
D	0019904	molecular_function	protein domain specific binding
D	0019985	biological_process	translesion synthesis
D	0030968	biological_process	endoplasmic reticulum unfolded protein response
D	0030970	biological_process	retrograde protein transport, ER to cytosol
D	0031334	biological_process	positive regulation of protein-containing complex assembly
D	0031593	molecular_function	polyubiquitin modification-dependent protein binding
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
D	0032991	cellular_component	protein-containing complex
D	0033554	biological_process	cellular response to stress
D	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
D	0034605	biological_process	cellular response to heat
D	0034774	cellular_component	secretory granule lumen
D	0035331	biological_process	negative regulation of hippo signaling
D	0035578	cellular_component	azurophil granule lumen
D	0035617	biological_process	stress granule disassembly
D	0035800	molecular_function	deubiquitinase activator activity
D	0035861	cellular_component	site of double-strand break
D	0036297	biological_process	interstrand cross-link repair
D	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
D	0036503	biological_process	ERAD pathway
D	0036513	cellular_component	Derlin-1 retrotranslocation complex
D	0042288	molecular_function	MHC class I protein binding
D	0042802	molecular_function	identical protein binding
D	0042981	biological_process	regulation of apoptotic process
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0043531	molecular_function	ADP binding
D	0044389	molecular_function	ubiquitin-like protein ligase binding
D	0044877	molecular_function	protein-containing complex binding
D	0045184	biological_process	establishment of protein localization
D	0045202	cellular_component	synapse
D	0045732	biological_process	positive regulation of protein catabolic process
D	0045879	biological_process	negative regulation of smoothened signaling pathway
D	0046034	biological_process	ATP metabolic process
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0050807	biological_process	regulation of synapse organization
D	0051228	biological_process	mitotic spindle disassembly
D	0061775	molecular_function	cohesin loader activity
D	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
D	0070062	cellular_component	extracellular exosome
D	0070842	biological_process	aggresome assembly
D	0071218	biological_process	cellular response to misfolded protein
D	0072389	biological_process	flavin adenine dinucleotide catabolic process
D	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
D	0097352	biological_process	autophagosome maturation
D	0098978	cellular_component	glutamatergic synapse
D	0106300	biological_process	protein-DNA covalent cross-linking repair
D	0120186	biological_process	negative regulation of protein localization to chromatin
D	0140036	molecular_function	ubiquitin-modified protein reader activity
D	0140455	biological_process	cytoplasm protein quality control
D	0140584	molecular_function	chromatin extrusion motor activity
D	0140588	biological_process	chromatin looping
D	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
D	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
D	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
D	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
D	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
D	1903715	biological_process	regulation of aerobic respiration
D	1903843	biological_process	cellular response to arsenite ion
D	1903862	biological_process	positive regulation of oxidative phosphorylation
D	1904288	molecular_function	BAT3 complex binding
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	1904949	cellular_component	ATPase complex
D	1905634	biological_process	regulation of protein localization to chromatin
D	1990381	molecular_function	ubiquitin-specific protease binding
D	1990730	cellular_component	VCP-NSFL1C complex
D	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
D	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
D	2001171	biological_process	positive regulation of ATP biosynthetic process
E	0000502	cellular_component	proteasome complex
E	0003689	molecular_function	DNA clamp loader activity
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005811	cellular_component	lipid droplet
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006302	biological_process	double-strand break repair
E	0006338	biological_process	chromatin remodeling
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006734	biological_process	NADH metabolic process
E	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
E	0006914	biological_process	autophagy
E	0006974	biological_process	DNA damage response
E	0008289	molecular_function	lipid binding
E	0010494	cellular_component	cytoplasmic stress granule
E	0010498	biological_process	proteasomal protein catabolic process
E	0010918	biological_process	positive regulation of mitochondrial membrane potential
E	0016236	biological_process	macroautophagy
E	0016567	biological_process	protein ubiquitination
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0019079	biological_process	viral genome replication
E	0019903	molecular_function	protein phosphatase binding
E	0019904	molecular_function	protein domain specific binding
E	0019985	biological_process	translesion synthesis
E	0030968	biological_process	endoplasmic reticulum unfolded protein response
E	0030970	biological_process	retrograde protein transport, ER to cytosol
E	0031334	biological_process	positive regulation of protein-containing complex assembly
E	0031593	molecular_function	polyubiquitin modification-dependent protein binding
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
E	0032991	cellular_component	protein-containing complex
E	0033554	biological_process	cellular response to stress
E	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
E	0034605	biological_process	cellular response to heat
E	0034774	cellular_component	secretory granule lumen
E	0035331	biological_process	negative regulation of hippo signaling
E	0035578	cellular_component	azurophil granule lumen
E	0035617	biological_process	stress granule disassembly
E	0035800	molecular_function	deubiquitinase activator activity
E	0035861	cellular_component	site of double-strand break
E	0036297	biological_process	interstrand cross-link repair
E	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
E	0036503	biological_process	ERAD pathway
E	0036513	cellular_component	Derlin-1 retrotranslocation complex
E	0042288	molecular_function	MHC class I protein binding
E	0042802	molecular_function	identical protein binding
E	0042981	biological_process	regulation of apoptotic process
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0043531	molecular_function	ADP binding
E	0044389	molecular_function	ubiquitin-like protein ligase binding
E	0044877	molecular_function	protein-containing complex binding
E	0045184	biological_process	establishment of protein localization
E	0045202	cellular_component	synapse
E	0045732	biological_process	positive regulation of protein catabolic process
E	0045879	biological_process	negative regulation of smoothened signaling pathway
E	0046034	biological_process	ATP metabolic process
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050807	biological_process	regulation of synapse organization
E	0051228	biological_process	mitotic spindle disassembly
E	0061775	molecular_function	cohesin loader activity
E	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
E	0070062	cellular_component	extracellular exosome
E	0070842	biological_process	aggresome assembly
E	0071218	biological_process	cellular response to misfolded protein
E	0072389	biological_process	flavin adenine dinucleotide catabolic process
E	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
E	0097352	biological_process	autophagosome maturation
E	0098978	cellular_component	glutamatergic synapse
E	0106300	biological_process	protein-DNA covalent cross-linking repair
E	0120186	biological_process	negative regulation of protein localization to chromatin
E	0140036	molecular_function	ubiquitin-modified protein reader activity
E	0140455	biological_process	cytoplasm protein quality control
E	0140584	molecular_function	chromatin extrusion motor activity
E	0140588	biological_process	chromatin looping
E	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
E	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
E	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
E	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
E	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
E	1903715	biological_process	regulation of aerobic respiration
E	1903843	biological_process	cellular response to arsenite ion
E	1903862	biological_process	positive regulation of oxidative phosphorylation
E	1904288	molecular_function	BAT3 complex binding
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	1904949	cellular_component	ATPase complex
E	1905634	biological_process	regulation of protein localization to chromatin
E	1990381	molecular_function	ubiquitin-specific protease binding
E	1990730	cellular_component	VCP-NSFL1C complex
E	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
E	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
E	2001171	biological_process	positive regulation of ATP biosynthetic process
F	0000502	cellular_component	proteasome complex
F	0003689	molecular_function	DNA clamp loader activity
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005811	cellular_component	lipid droplet
F	0005829	cellular_component	cytosol
F	0006281	biological_process	DNA repair
F	0006302	biological_process	double-strand break repair
F	0006338	biological_process	chromatin remodeling
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006734	biological_process	NADH metabolic process
F	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
F	0006914	biological_process	autophagy
F	0006974	biological_process	DNA damage response
F	0008289	molecular_function	lipid binding
F	0010494	cellular_component	cytoplasmic stress granule
F	0010498	biological_process	proteasomal protein catabolic process
F	0010918	biological_process	positive regulation of mitochondrial membrane potential
F	0016236	biological_process	macroautophagy
F	0016567	biological_process	protein ubiquitination
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0019079	biological_process	viral genome replication
F	0019903	molecular_function	protein phosphatase binding
F	0019904	molecular_function	protein domain specific binding
F	0019985	biological_process	translesion synthesis
F	0030968	biological_process	endoplasmic reticulum unfolded protein response
F	0030970	biological_process	retrograde protein transport, ER to cytosol
F	0031334	biological_process	positive regulation of protein-containing complex assembly
F	0031593	molecular_function	polyubiquitin modification-dependent protein binding
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
F	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
F	0032991	cellular_component	protein-containing complex
F	0033554	biological_process	cellular response to stress
F	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
F	0034605	biological_process	cellular response to heat
F	0034774	cellular_component	secretory granule lumen
F	0035331	biological_process	negative regulation of hippo signaling
F	0035578	cellular_component	azurophil granule lumen
F	0035617	biological_process	stress granule disassembly
F	0035800	molecular_function	deubiquitinase activator activity
F	0035861	cellular_component	site of double-strand break
F	0036297	biological_process	interstrand cross-link repair
F	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
F	0036503	biological_process	ERAD pathway
F	0036513	cellular_component	Derlin-1 retrotranslocation complex
F	0042288	molecular_function	MHC class I protein binding
F	0042802	molecular_function	identical protein binding
F	0042981	biological_process	regulation of apoptotic process
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0043531	molecular_function	ADP binding
F	0044389	molecular_function	ubiquitin-like protein ligase binding
F	0044877	molecular_function	protein-containing complex binding
F	0045184	biological_process	establishment of protein localization
F	0045202	cellular_component	synapse
F	0045732	biological_process	positive regulation of protein catabolic process
F	0045879	biological_process	negative regulation of smoothened signaling pathway
F	0046034	biological_process	ATP metabolic process
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0050807	biological_process	regulation of synapse organization
F	0051228	biological_process	mitotic spindle disassembly
F	0061775	molecular_function	cohesin loader activity
F	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
F	0070062	cellular_component	extracellular exosome
F	0070842	biological_process	aggresome assembly
F	0071218	biological_process	cellular response to misfolded protein
F	0072389	biological_process	flavin adenine dinucleotide catabolic process
F	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
F	0097352	biological_process	autophagosome maturation
F	0098978	cellular_component	glutamatergic synapse
F	0106300	biological_process	protein-DNA covalent cross-linking repair
F	0120186	biological_process	negative regulation of protein localization to chromatin
F	0140036	molecular_function	ubiquitin-modified protein reader activity
F	0140455	biological_process	cytoplasm protein quality control
F	0140584	molecular_function	chromatin extrusion motor activity
F	0140588	biological_process	chromatin looping
F	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
F	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
F	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
F	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
F	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
F	1903715	biological_process	regulation of aerobic respiration
F	1903843	biological_process	cellular response to arsenite ion
F	1903862	biological_process	positive regulation of oxidative phosphorylation
F	1904288	molecular_function	BAT3 complex binding
F	1904813	cellular_component	ficolin-1-rich granule lumen
F	1904949	cellular_component	ATPase complex
F	1905634	biological_process	regulation of protein localization to chromatin
F	1990381	molecular_function	ubiquitin-specific protease binding
F	1990730	cellular_component	VCP-NSFL1C complex
F	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
F	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
F	2001171	biological_process	positive regulation of ATP biosynthetic process
W	0002020	molecular_function	protease binding
W	0005047	molecular_function	signal recognition particle binding
W	0005515	molecular_function	protein binding
W	0005769	cellular_component	early endosome
W	0005770	cellular_component	late endosome
W	0005783	cellular_component	endoplasmic reticulum
W	0005789	cellular_component	endoplasmic reticulum membrane
W	0006986	biological_process	response to unfolded protein
W	0010498	biological_process	proteasomal protein catabolic process
W	0015031	biological_process	protein transport
W	0016020	cellular_component	membrane
W	0030968	biological_process	endoplasmic reticulum unfolded protein response
W	0030970	biological_process	retrograde protein transport, ER to cytosol
W	0031398	biological_process	positive regulation of protein ubiquitination
W	0031625	molecular_function	ubiquitin protein ligase binding
W	0031648	biological_process	protein destabilization
W	0033554	biological_process	cellular response to stress
W	0034620	biological_process	cellular response to unfolded protein
W	0036502	cellular_component	Derlin-1-VIMP complex
W	0036503	biological_process	ERAD pathway
W	0036513	cellular_component	Derlin-1 retrotranslocation complex
W	0038023	molecular_function	signaling receptor activity
W	0042288	molecular_function	MHC class I protein binding
W	0042802	molecular_function	identical protein binding
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0044322	cellular_component	endoplasmic reticulum quality control compartment
W	0044877	molecular_function	protein-containing complex binding
W	0045184	biological_process	establishment of protein localization
W	0051117	molecular_function	ATPase binding
W	0071218	biological_process	cellular response to misfolded protein
W	1990381	molecular_function	ubiquitin-specific protease binding
X	0002020	molecular_function	protease binding
X	0005047	molecular_function	signal recognition particle binding
X	0005515	molecular_function	protein binding
X	0005769	cellular_component	early endosome
X	0005770	cellular_component	late endosome
X	0005783	cellular_component	endoplasmic reticulum
X	0005789	cellular_component	endoplasmic reticulum membrane
X	0006986	biological_process	response to unfolded protein
X	0010498	biological_process	proteasomal protein catabolic process
X	0015031	biological_process	protein transport
X	0016020	cellular_component	membrane
X	0030968	biological_process	endoplasmic reticulum unfolded protein response
X	0030970	biological_process	retrograde protein transport, ER to cytosol
X	0031398	biological_process	positive regulation of protein ubiquitination
X	0031625	molecular_function	ubiquitin protein ligase binding
X	0031648	biological_process	protein destabilization
X	0033554	biological_process	cellular response to stress
X	0034620	biological_process	cellular response to unfolded protein
X	0036502	cellular_component	Derlin-1-VIMP complex
X	0036503	biological_process	ERAD pathway
X	0036513	cellular_component	Derlin-1 retrotranslocation complex
X	0038023	molecular_function	signaling receptor activity
X	0042288	molecular_function	MHC class I protein binding
X	0042802	molecular_function	identical protein binding
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0044322	cellular_component	endoplasmic reticulum quality control compartment
X	0044877	molecular_function	protein-containing complex binding
X	0045184	biological_process	establishment of protein localization
X	0051117	molecular_function	ATPase binding
X	0071218	biological_process	cellular response to misfolded protein
X	1990381	molecular_function	ubiquitin-specific protease binding
Y	0002020	molecular_function	protease binding
Y	0005047	molecular_function	signal recognition particle binding
Y	0005515	molecular_function	protein binding
Y	0005769	cellular_component	early endosome
Y	0005770	cellular_component	late endosome
Y	0005783	cellular_component	endoplasmic reticulum
Y	0005789	cellular_component	endoplasmic reticulum membrane
Y	0006986	biological_process	response to unfolded protein
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0015031	biological_process	protein transport
Y	0016020	cellular_component	membrane
Y	0030968	biological_process	endoplasmic reticulum unfolded protein response
Y	0030970	biological_process	retrograde protein transport, ER to cytosol
Y	0031398	biological_process	positive regulation of protein ubiquitination
Y	0031625	molecular_function	ubiquitin protein ligase binding
Y	0031648	biological_process	protein destabilization
Y	0033554	biological_process	cellular response to stress
Y	0034620	biological_process	cellular response to unfolded protein
Y	0036502	cellular_component	Derlin-1-VIMP complex
Y	0036503	biological_process	ERAD pathway
Y	0036513	cellular_component	Derlin-1 retrotranslocation complex
Y	0038023	molecular_function	signaling receptor activity
Y	0042288	molecular_function	MHC class I protein binding
Y	0042802	molecular_function	identical protein binding
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0044322	cellular_component	endoplasmic reticulum quality control compartment
Y	0044877	molecular_function	protein-containing complex binding
Y	0045184	biological_process	establishment of protein localization
Y	0051117	molecular_function	ATPase binding
Y	0071218	biological_process	cellular response to misfolded protein
Y	1990381	molecular_function	ubiquitin-specific protease binding
Z	0002020	molecular_function	protease binding
Z	0005047	molecular_function	signal recognition particle binding
Z	0005515	molecular_function	protein binding
Z	0005769	cellular_component	early endosome
Z	0005770	cellular_component	late endosome
Z	0005783	cellular_component	endoplasmic reticulum
Z	0005789	cellular_component	endoplasmic reticulum membrane
Z	0006986	biological_process	response to unfolded protein
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0015031	biological_process	protein transport
Z	0016020	cellular_component	membrane
Z	0030968	biological_process	endoplasmic reticulum unfolded protein response
Z	0030970	biological_process	retrograde protein transport, ER to cytosol
Z	0031398	biological_process	positive regulation of protein ubiquitination
Z	0031625	molecular_function	ubiquitin protein ligase binding
Z	0031648	biological_process	protein destabilization
Z	0033554	biological_process	cellular response to stress
Z	0034620	biological_process	cellular response to unfolded protein
Z	0036502	cellular_component	Derlin-1-VIMP complex
Z	0036503	biological_process	ERAD pathway
Z	0036513	cellular_component	Derlin-1 retrotranslocation complex
Z	0038023	molecular_function	signaling receptor activity
Z	0042288	molecular_function	MHC class I protein binding
Z	0042802	molecular_function	identical protein binding
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0044322	cellular_component	endoplasmic reticulum quality control compartment
Z	0044877	molecular_function	protein-containing complex binding
Z	0045184	biological_process	establishment of protein localization
Z	0051117	molecular_function	ATPase binding
Z	0071218	biological_process	cellular response to misfolded protein
Z	1990381	molecular_function	ubiquitin-specific protease binding

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. ViVMaATNrpnsIDpALr.R

Chain	Residue	Details
A	VAL341-ARG359
A	VAL617-ARG635

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:20512113

Chain	Residue	Details
A	PRO247
D	PRO247
D	ASN348
D	HIS384
E	PRO247
E	ASN348
E	HIS384
F	PRO247
F	ASN348
F	HIS384
A	ASN348
A	HIS384
B	PRO247
B	ASN348
B	HIS384
C	PRO247
C	ASN348
C	HIS384

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
A	GLY521
B	GLY521
C	GLY521
D	GLY521
E	GLY521
F	GLY521

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER37
Z	GLY32-GLY69
Z	MET116-MET122
Z	GLY167-VAL170
B	SER37
C	SER37
D	SER37
E	SER37
F	SER37
Y	GLY32-GLY69
Y	MET116-MET122
Y	GLY167-VAL170

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N6,N6,N6-trimethyllysine; by VCPKMT => ECO:0000269|PubMed:22948820, ECO:0000269|PubMed:23349634

Chain	Residue	Details
A	LYS315
B	LYS315
C	LYS315
D	LYS315
E	LYS315
F	LYS315

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
A	THR436
B	THR436
C	THR436
D	THR436
E	THR436
F	THR436

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER462
E	SER702
F	SER462
F	SER702
A	SER702
B	SER462
B	SER702
C	SER462
C	SER702
D	SER462
D	SER702
E	SER462

---

site_id	SWS_FT_FI7
Number of Residues	18
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
A	LYS502
D	LYS502
D	LYS505
D	LYS754
E	LYS502
E	LYS505
E	LYS754
F	LYS502
F	LYS505
F	LYS754
A	LYS505
A	LYS754
B	LYS502
B	LYS505
B	LYS754
C	LYS502
C	LYS505
C	LYS754

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
A	LYS668
B	LYS668
C	LYS668
D	LYS668
E	LYS668
F	LYS668

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SER770
E	SER775
F	SER770
F	SER775
A	SER775
B	SER770
B	SER775
C	SER770
C	SER775
D	SER770
D	SER775
E	SER770

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
A	SER787
B	SER787
C	SER787
D	SER787
E	SER787
F	SER787
Z	SER201
Z	GLN251

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
A	TYR805
B	TYR805
C	TYR805
D	TYR805
E	TYR805
F	TYR805

---