7Y3G
Cryo-EM structure of a class A orphan GPCR
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45683.4 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | N | Nanobody 35 | polymer | 157 | 17057.3 | 1 | Lama glama | ||
5 | R | G-protein coupled receptor 12 | polymer | 378 | 42057.0 | 1 | UniProt (P47775) Pfam (PF00001) In PDB | Homo sapiens (human) |
Sequence modifications
A: 1 - 394 (UniProt: P63092)
R: 1 - 334 (UniProt: P47775)
PDB | External Database | Details |
---|---|---|
Asn 54 | Ser 54 | engineered mutation |
Ala 226 | Gly 226 | engineered mutation |
Ala 268 | Glu 268 | engineered mutation |
Lys 271 | Asn 271 | engineered mutation |
Asp 274 | Lys 274 | engineered mutation |
Lys 280 | Arg 280 | engineered mutation |
Asp 284 | Thr 284 | engineered mutation |
Thr 285 | Ile 285 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -43 | - | initiating methionine |
Lys -42 | - | expression tag |
Thr -41 | - | expression tag |
Ile -40 | - | expression tag |
Ile -39 | - | expression tag |
Ala -38 | - | expression tag |
Leu -37 | - | expression tag |
Ser -36 | - | expression tag |
Tyr -35 | - | expression tag |
Ile -34 | - | expression tag |
Phe -33 | - | expression tag |
Cys -32 | - | expression tag |
Leu -31 | - | expression tag |
Val -30 | - | expression tag |
Phe -29 | - | expression tag |
Ala -28 | - | expression tag |
His -27 | - | expression tag |
His -26 | - | expression tag |
His -25 | - | expression tag |
His -24 | - | expression tag |
His -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
Asp -17 | - | expression tag |
Tyr -16 | - | expression tag |
Lys -15 | - | expression tag |
Asp -14 | - | expression tag |
Asp -13 | - | expression tag |
Asp -12 | - | expression tag |
Asp -11 | - | expression tag |
Lys -10 | - | expression tag |
Glu -9 | - | expression tag |
Asn -8 | - | expression tag |
Leu -7 | - | expression tag |
Tyr -6 | - | expression tag |
Phe -5 | - | expression tag |
Gln -4 | - | expression tag |
Ser -3 | - | expression tag |
Gly -2 | - | expression tag |
Ala -1 | - | expression tag |
Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 150075.8 | |
All* | Total formula weight | 150075.8 |