7Y1T
Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-V | polymer | 635 | 69812.7 | 1 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) | Homo sapiens (human) | Vitronectin receptor,Vitronectin receptor subunit alpha |
| 2 | B (B) | Integrin beta-8 | polymer | 477 | 53017.4 | 1 | UniProt (P26012) Pfam (PF17205) Pfam (PF00362) | Homo sapiens (human) | |
| 3 | C (D) | Transforming growth factor beta-1 proprotein | polymer | 377 | 43010.4 | 1 | UniProt (P01137) Pfam (PF00688) Pfam (PF00019) | Homo sapiens (human) | |
| 4 | D (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 1 | In PDB GlyTouCan (G47362BJ) | |||
| 5 | E, F (C, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | G (G) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB | |||
| 7 | H, M, N, O, R (A, B, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 8 | I, J, K, L, P (A, B) | CALCIUM ION | non-polymer | 40.1 | 5 | Chemie (CA) | |||
| 9 | Q (B) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) |
Sequence modifications
A: -29 - 596 (UniProt: P06756)
B: 1 - 456 (UniProt: P26012)
D: 1 - 361 (UniProt: P01137)
| PDB | External Database | Details |
|---|---|---|
| Gly 400 | - | insertion |
| Cys 401 | Met 430 | engineered mutation |
| Thr 597 | - | expression tag |
| Gly 598 | - | expression tag |
| Gly 599 | - | expression tag |
| Leu 600 | - | expression tag |
| Glu 601 | - | expression tag |
| Val 602 | - | expression tag |
| Leu 603 | - | expression tag |
| Phe 604 | - | expression tag |
| Gln 605 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | initiating methionine |
| Asp -19 | - | expression tag |
| Met -18 | - | expression tag |
| Arg -17 | - | expression tag |
| Val -16 | - | expression tag |
| Pro -15 | - | expression tag |
| Ala -14 | - | expression tag |
| Gln -13 | - | expression tag |
| Leu -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Trp -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Val -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Cys 259 | Val 301 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -15 | - | initiating methionine |
| Pro -14 | - | expression tag |
| Leu -13 | - | expression tag |
| Leu -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Pro -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Trp -5 | - | expression tag |
| Ala -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 165840.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2549.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1361.4 | |
| All* | Total formula weight | 169751.2 |
