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7Y1T

Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2

Functional Information from GO Data
ChainGOidnamespacecontents
A0007155biological_processcell adhesion
A0008305cellular_componentintegrin complex
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000902biological_processcell morphogenesis
D0001570biological_processvasculogenesis
D0001657biological_processureteric bud development
D0001666biological_processresponse to hypoxia
D0001763biological_processmorphogenesis of a branching structure
D0001775biological_processcell activation
D0001837biological_processepithelial to mesenchymal transition
D0001843biological_processneural tube closure
D0002028biological_processregulation of sodium ion transport
D0002040biological_processsprouting angiogenesis
D0002062biological_processchondrocyte differentiation
D0002069biological_processcolumnar/cuboidal epithelial cell maturation
D0002244biological_processhematopoietic progenitor cell differentiation
D0002248biological_processconnective tissue replacement involved in inflammatory response wound healing
D0002460biological_processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
D0002513biological_processtolerance induction to self antigen
D0002859biological_processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
D0003179biological_processheart valve morphogenesis
D0003180biological_processaortic valve morphogenesis
D0005114molecular_functiontype II transforming growth factor beta receptor binding
D0005125molecular_functioncytokine activity
D0005160molecular_functiontransforming growth factor beta receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005796cellular_componentGolgi lumen
D0005886cellular_componentplasma membrane
D0005902cellular_componentmicrovillus
D0006611biological_processprotein export from nucleus
D0006754biological_processATP biosynthetic process
D0006796biological_processphosphate-containing compound metabolic process
D0006874biological_processintracellular calcium ion homeostasis
D0006954biological_processinflammatory response
D0007179biological_processtransforming growth factor beta receptor signaling pathway
D0007219biological_processNotch signaling pathway
D0007406biological_processnegative regulation of neuroblast proliferation
D0007435biological_processsalivary gland morphogenesis
D0007492biological_processendoderm development
D0007507biological_processheart development
D0007565biological_processfemale pregnancy
D0008083molecular_functiongrowth factor activity
D0008283biological_processcell population proliferation
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0008354biological_processgerm cell migration
D0009410biological_processresponse to xenobiotic stimulus
D0009611biological_processresponse to wounding
D0009749biological_processresponse to glucose
D0009986cellular_componentcell surface
D0010467biological_processgene expression
D0010468biological_processregulation of gene expression
D0010575biological_processpositive regulation of vascular endothelial growth factor production
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010716biological_processnegative regulation of extracellular matrix disassembly
D0010718biological_processpositive regulation of epithelial to mesenchymal transition
D0010742biological_processmacrophage derived foam cell differentiation
D0010763biological_processpositive regulation of fibroblast migration
D0010936biological_processnegative regulation of macrophage cytokine production
D0014003biological_processoligodendrocyte development
D0014008biological_processpositive regulation of microglia differentiation
D0016202biological_processregulation of striated muscle tissue development
D0019899molecular_functionenzyme binding
D0021915biological_processneural tube development
D0030141cellular_componentsecretory granule
D0030214biological_processhyaluronan catabolic process
D0030217biological_processT cell differentiation
D0030279biological_processnegative regulation of ossification
D0030308biological_processnegative regulation of cell growth
D0030316biological_processosteoclast differentiation
D0030334biological_processregulation of cell migration
D0030335biological_processpositive regulation of cell migration
D0030424cellular_componentaxon
D0030879biological_processmammary gland development
D0031012cellular_componentextracellular matrix
D0031093cellular_componentplatelet alpha granule lumen
D0031100biological_processanimal organ regeneration
D0031293biological_processmembrane protein intracellular domain proteolysis
D0031334biological_processpositive regulation of protein-containing complex assembly
D0031536biological_processpositive regulation of exit from mitosis
D0032355biological_processresponse to estradiol
D0032570biological_processresponse to progesterone
D0032667biological_processregulation of interleukin-23 production
D0032700biological_processnegative regulation of interleukin-17 production
D0032740biological_processpositive regulation of interleukin-17 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032801biological_processreceptor catabolic process
D0032930biological_processpositive regulation of superoxide anion generation
D0032943biological_processmononuclear cell proliferation
D0032956biological_processregulation of actin cytoskeleton organization
D0032967biological_processpositive regulation of collagen biosynthetic process
D0033280biological_processresponse to vitamin D
D0034616biological_processresponse to laminar fluid shear stress
D0034713molecular_functiontype I transforming growth factor beta receptor binding
D0034714molecular_functiontype III transforming growth factor beta receptor binding
D0035800molecular_functiondeubiquitinase activator activity
D0035902biological_processresponse to immobilization stress
D0036446biological_processmyofibroblast differentiation
D0042098biological_processT cell proliferation
D0042110biological_processT cell activation
D0042127biological_processregulation of cell population proliferation
D0042130biological_processnegative regulation of T cell proliferation
D0042306biological_processregulation of protein import into nucleus
D0042307biological_processpositive regulation of protein import into nucleus
D0042475biological_processodontogenesis of dentin-containing tooth
D0042482biological_processpositive regulation of odontogenesis
D0042552biological_processmyelination
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043029biological_processT cell homeostasis
D0043065biological_processpositive regulation of apoptotic process
D0043117biological_processpositive regulation of vascular permeability
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043129biological_processsurfactant homeostasis
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043410biological_processpositive regulation of MAPK cascade
D0043536biological_processpositive regulation of blood vessel endothelial cell migration
D0043537biological_processnegative regulation of blood vessel endothelial cell migration
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0044877molecular_functionprotein-containing complex binding
D0045066biological_processregulatory T cell differentiation
D0045216biological_processcell-cell junction organization
D0045471biological_processresponse to ethanol
D0045589biological_processregulation of regulatory T cell differentiation
D0045591biological_processpositive regulation of regulatory T cell differentiation
D0045596biological_processnegative regulation of cell differentiation
D0045597biological_processpositive regulation of cell differentiation
D0045599biological_processnegative regulation of fat cell differentiation
D0045662biological_processnegative regulation of myoblast differentiation
D0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
D0045786biological_processnegative regulation of cell cycle
D0045892biological_processnegative regulation of DNA-templated transcription
D0045893biological_processpositive regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046716biological_processmuscle cell cellular homeostasis
D0048146biological_processpositive regulation of fibroblast proliferation
D0048286biological_processlung alveolus development
D0048298biological_processpositive regulation of isotype switching to IgA isotypes
D0048535biological_processlymph node development
D0048565biological_processdigestive tract development
D0048642biological_processnegative regulation of skeletal muscle tissue development
D0048661biological_processpositive regulation of smooth muscle cell proliferation
D0048839biological_processinner ear development
D0050673biological_processepithelial cell proliferation
D0050679biological_processpositive regulation of epithelial cell proliferation
D0050680biological_processnegative regulation of epithelial cell proliferation
D0050714biological_processpositive regulation of protein secretion
D0050729biological_processpositive regulation of inflammatory response
D0050765biological_processnegative regulation of phagocytosis
D0050832biological_processdefense response to fungus
D0050868biological_processnegative regulation of T cell activation
D0050921biological_processpositive regulation of chemotaxis
D0051130biological_processpositive regulation of cellular component organization
D0051152biological_processpositive regulation of smooth muscle cell differentiation
D0051240biological_processpositive regulation of multicellular organismal process
D0051247biological_processpositive regulation of protein metabolic process
D0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
D0051402biological_processneuron apoptotic process
D0051726biological_processregulation of cell cycle
D0051781biological_processpositive regulation of cell division
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0055010biological_processventricular cardiac muscle tissue morphogenesis
D0055091biological_processphospholipid homeostasis
D0060070biological_processcanonical Wnt signaling pathway
D0060312biological_processregulation of blood vessel remodeling
D0060325biological_processface morphogenesis
D0060364biological_processfrontal suture morphogenesis
D0060391biological_processpositive regulation of SMAD protein signal transduction
D0060435biological_processbronchiole development
D0060744biological_processmammary gland branching involved in thelarche
D0060751biological_processbranch elongation involved in mammary gland duct branching
D0060762biological_processregulation of branching involved in mammary gland duct morphogenesis
D0061035biological_processregulation of cartilage development
D0061298biological_processretina vasculature development in camera-type eye
D0061448biological_processconnective tissue development
D0061520biological_processLangerhans cell differentiation
D0070168biological_processnegative regulation of biomineral tissue development
D0070173biological_processregulation of enamel mineralization
D0070306biological_processlens fiber cell differentiation
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070723biological_processresponse to cholesterol
D0071260biological_processcellular response to mechanical stimulus
D0071333biological_processcellular response to glucose stimulus
D0071363biological_processcellular response to growth factor stimulus
D0071404biological_processcellular response to low-density lipoprotein particle stimulus
D0071456biological_processcellular response to hypoxia
D0071479biological_processcellular response to ionizing radiation
D0071549biological_processcellular response to dexamethasone stimulus
D0071560biological_processcellular response to transforming growth factor beta stimulus
D0071677biological_processpositive regulation of mononuclear cell migration
D0071895biological_processodontoblast differentiation
D0072089biological_processstem cell proliferation
D0072562cellular_componentblood microparticle
D0085029biological_processextracellular matrix assembly
D0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0097191biological_processextrinsic apoptotic signaling pathway
D0097421biological_processliver regeneration
D0098586biological_processcellular response to virus
D0141091biological_processtransforming growth factor beta receptor superfamily signaling pathway
D1900126biological_processnegative regulation of hyaluronan biosynthetic process
D1900182biological_processpositive regulation of protein localization to nucleus
D1901203biological_processpositive regulation of extracellular matrix assembly
D1902074biological_processresponse to salt
D1902462biological_processpositive regulation of mesenchymal stem cell proliferation
D1902893biological_processregulation of miRNA transcription
D1902894biological_processnegative regulation of miRNA transcription
D1902895biological_processpositive regulation of miRNA transcription
D1903077biological_processnegative regulation of protein localization to plasma membrane
D1904018biological_processpositive regulation of vasculature development
D1904894biological_processpositive regulation of receptor signaling pathway via STAT
D1905005biological_processregulation of epithelial to mesenchymal transition involved in endocardial cushion formation
D1905641biological_processcellular response to acetaldehyde
D1990314biological_processcellular response to insulin-like growth factor stimulus
D1990402biological_processembryonic liver development
D2000048biological_processnegative regulation of cell-cell adhesion mediated by cadherin
D2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
D2000353biological_processpositive regulation of endothelial cell apoptotic process
D2000636biological_processpositive regulation of primary miRNA processing
D2000648biological_processpositive regulation of stem cell proliferation
D2000727biological_processpositive regulation of cardiac muscle cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IhePkgYhanfClGpC
ChainResidueDetails
DILE282-CYS297

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by FURIN => ECO:0000269|PubMed:7737999
ChainResidueDetails
DARG249
AASP292
AASP349
AASP351
AASP353
APHE355
AASP357
AASP414
AASP416
AASN418
ATYR420
BGLU212
AASP422
AASP234
AILE236
AASP238
AASP284
AASN286
AASP288
ATYR290

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:28117447, ECO:0007744|PDB:5FFO
ChainResidueDetails
DASN53

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
DASN107
DASN147
BASP209
BPRO211

site_idSWS_FT_FI4
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN191
BASN414
BASN424

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM1
ChainResidueDetails
BASN360
BASN379

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31792290, ECO:0007744|PDB:6OM1, ECO:0007744|PDB:6OM2
ChainResidueDetails
BASN389

237992

PDB entries from 2025-06-25

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