7Y0H
Cryo-EM structure of human IgM-Fc in complex with the J chain and the P. falciparum VAR2CSA FCR3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Immunoglobulin heavy constant mu | polymer | 383 | 41875.8 | 10 | UniProt (P01871) Pfam (PF07654) | Homo sapiens (human) | Ig mu chain C region,Ig mu chain C region BOT,Ig mu chain C region GAL,Ig mu chain C region OU |
| 2 | I (J) | Immunoglobulin J chain | polymer | 136 | 15483.3 | 1 | UniProt (P01591) Pfam (PF15097) | Homo sapiens (human) | Joining chain of multimeric IgA and IgM |
| 3 | L (M) | Erythrocyte membrane protein 1 | polymer | 2636 | 306371.4 | 1 | UniProt (Q6UDW7) Pfam (PF05424) Pfam (PF15448) | Plasmodium falciparum (malaria parasite P. falciparum) | |
| 4 | M (I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | N, O, P, Q, R... (A, B, C, D, E...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) |
Sequence modifications
A, B, C, D, E, F, G, H, K, L: 229 - 576 (UniProt: P01871)
M: 1 - 2628 (UniProt: Q6UDW7)
| PDB | External Database | Details |
|---|---|---|
| Ala 194 | - | expression tag |
| Ser 195 | - | expression tag |
| Ala 196 | - | expression tag |
| Trp 197 | - | expression tag |
| Ser 198 | - | expression tag |
| His 199 | - | expression tag |
| Pro 200 | - | expression tag |
| Gln 201 | - | expression tag |
| Phe 202 | - | expression tag |
| Glu 203 | - | expression tag |
| Lys 204 | - | expression tag |
| Gly 205 | - | expression tag |
| Gly 206 | - | expression tag |
| Gly 207 | - | expression tag |
| Ser 208 | - | expression tag |
| Gly 209 | - | expression tag |
| Gly 210 | - | expression tag |
| Gly 211 | - | expression tag |
| Ser 212 | - | expression tag |
| Gly 213 | - | expression tag |
| Gly 214 | - | expression tag |
| Ser 215 | - | expression tag |
| Ala 216 | - | expression tag |
| Trp 217 | - | expression tag |
| Ser 218 | - | expression tag |
| His 219 | - | expression tag |
| Pro 220 | - | expression tag |
| Gln 221 | - | expression tag |
| Phe 222 | - | expression tag |
| Glu 223 | - | expression tag |
| Lys 224 | - | expression tag |
| Ile 225 | - | expression tag |
| Asp 226 | - | expression tag |
| Thr 227 | - | expression tag |
| Thr 228 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 2629 | - | expression tag |
| His 2630 | - | expression tag |
| His 2631 | - | expression tag |
| His 2632 | - | expression tag |
| His 2633 | - | expression tag |
| His 2634 | - | expression tag |
| His 2635 | - | expression tag |
| His 2636 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 740612.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2212.1 | |
| All* | Total formula weight | 743248.9 |
