7XZX

Cryo-EM structure of the nucleosome in complex with p53 DNA-binding domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Histone H3.1	polymer	139	15719.4	2	UniProt (P68431) Pfam (PF00125) In PDB	Homo sapiens (human)	Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l
2	B, F	Histone H4	polymer	106	11676.7	2	UniProt (P62805) Pfam (PF15511) In PDB	Homo sapiens (human)
3	C, G	Histone H2A type 1-B/E	polymer	133	14447.8	2	UniProt (P04908) Pfam (PF00125) Pfam (PF16211) In PDB	Homo sapiens (human)	Histone H2A.2,Histone H2A/a,Histone H2A/m
4	D, H	Histone H2B type 1-J	polymer	129	14217.5	2	UniProt (P06899) Pfam (PF00125) In PDB	Homo sapiens (human)	Histone H2B.1,Histone H2B.r,H2B/r
5	I	DNA (193-MER)	polymer	193	59417.8	1		synthetic construct
6	J	DNA (193-MER)	polymer	193	59760.0	1		synthetic construct
7	K, L, M, N	Cellular tumor antigen p53	polymer	202	22659.8	4	UniProt (P04637) Pfam (PF00870) In PDB	Homo sapiens (human)	Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53

Sequence modifications

A, E: 1 - 135 (UniProt: P68431)

B, F: 0 - 102 (UniProt: P62805)

C, G: 0 - 129 (UniProt: P04908)

D, H: -3 - 122 (UniProt: P06899)

K, L, M, N: 94 - 293 (UniProt: P04637)

PDB	External Database	Details
Gly 92	-	expression tag
Pro 93	-	expression tag

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.