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7XYD

Crystal structure of TMPRSS2 in complex with Nafamostat

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, B)
Transmembrane protease serine 2 catalytic chainpolymer14616054.72UniProt (O15393)
Pfam (PF15494)
Homo sapiens (human)
2B, D
(C, D)
Transmembrane protease serine 2 catalytic chainpolymer24927856.72UniProt (O15393)
Pfam (PF00089)
Homo sapiens (human)
3E, H
(A, B)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.22Chemie (NAG)
4F, I
(A, B)
CALCIUM IONnon-polymer40.12Chemie (CA)
5G, J
(C, D)
4-carbamimidamidobenzoic acidnon-polymer179.22Chemie (GBS)
6K, L, M, N
(A, C, B, D)
waterwater18.0153Chemie (HOH)
Sequence modifications
A, B: 109 - 254 (UniProt: O15393)
PDBExternal DatabaseDetails
Asp 250Ser 250engineered mutation
Asp 251Ser 251engineered mutation
Asp 252Arg 252engineered mutation
Asp 253Gln 253engineered mutation
Lys 254Ser 254engineered mutation
C, D: 256 - 492 (UniProt: O15393)
PDBExternal DatabaseDetails
Glu 493-expression tag
Phe 494-expression tag
Val 495-expression tag
Glu 496-expression tag
His 497-expression tag
His 498-expression tag
His 499-expression tag
His 500-expression tag
His 501-expression tag
His 502-expression tag
His 503-expression tag
His 504-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight87822.8
Non-Polymers*Number of molecules6
Total formula weight880.9
All*Total formula weight88703.7
*Water molecules are not included.

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PDB entries from 2024-11-20

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