7XYD
Crystal structure of TMPRSS2 in complex with Nafamostat
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C (A, B) | Transmembrane protease serine 2 catalytic chain | polymer | 146 | 16054.7 | 2 | UniProt (O15393) Pfam (PF15494) | Homo sapiens (human) | |
2 | B, D (C, D) | Transmembrane protease serine 2 catalytic chain | polymer | 249 | 27856.7 | 2 | UniProt (O15393) Pfam (PF00089) | Homo sapiens (human) | |
3 | E, H (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
4 | F, I (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
5 | G, J (C, D) | 4-carbamimidamidobenzoic acid | non-polymer | 179.2 | 2 | Chemie (GBS) | |||
6 | K, L, M, N (A, C, B, D) | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A, B: 109 - 254 (UniProt: O15393)
C, D: 256 - 492 (UniProt: O15393)
PDB | External Database | Details |
---|---|---|
Asp 250 | Ser 250 | engineered mutation |
Asp 251 | Ser 251 | engineered mutation |
Asp 252 | Arg 252 | engineered mutation |
Asp 253 | Gln 253 | engineered mutation |
Lys 254 | Ser 254 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Glu 493 | - | expression tag |
Phe 494 | - | expression tag |
Val 495 | - | expression tag |
Glu 496 | - | expression tag |
His 497 | - | expression tag |
His 498 | - | expression tag |
His 499 | - | expression tag |
His 500 | - | expression tag |
His 501 | - | expression tag |
His 502 | - | expression tag |
His 503 | - | expression tag |
His 504 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 87822.8 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 880.9 | |
All* | Total formula weight | 88703.7 |