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7XYD

Crystal structure of TMPRSS2 in complex with Nafamostat

Functional Information from GO Data
ChainGOidnamespacecontents
A0016020cellular_componentmembrane
B0016020cellular_componentmembrane
C0004252molecular_functionserine-type endopeptidase activity
C0006508biological_processproteolysis
D0004252molecular_functionserine-type endopeptidase activity
D0006508biological_processproteolysis
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC
ChainResidueDetails
CVAL292-CYS297

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV
ChainResidueDetails
CASP435-VAL446

site_idPS01209
Number of Residues23
DetailsLDLRA_1 LDL-receptor class A (LDLRA) domain signature. CInpsnw.CDgvsHCpgg.EDEnr...C
ChainResidueDetails
ACYS126-CYS148

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Charge relay system => ECO:0000250
ChainResidueDetails
CHIS296
CASP345
DHIS296
DASP345

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Charge relay system
ChainResidueDetails
CSER441
DSER441

226707

PDB entries from 2024-10-30

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