7XVY

Human Estrogen Receptor beta Ligand-binding Domain in Complex with S-DPN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Estrogen receptor beta	polymer	247	27702.6	2	UniProt (Q92731) Pfam (PF00104)	Homo sapiens (human)	ER-beta,Nuclear receptor subfamily 3 group A member 2
2	C, D (C, D)	Nuclear receptor coactivator 1	polymer	13	1386.6	2	UniProt (Q15788)	Homo sapiens	NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1
3	E, F (A, B)	(2~{S})-2,3-bis(4-hydroxyphenyl)propanenitrile	non-polymer		239.3	2	Chemie (I0K)
4	G, H, I, J (A, B, C, D)	water	water		18.0	320	Chemie (HOH)

Sequence modifications

A, B: 261 - 500 (UniProt: Q92731)

PDB	External Database	Details
Gly 256	-	expression tag
Pro 257	-	expression tag
Leu 258	-	expression tag
Gly 259	-	expression tag
Ser 260	-	expression tag
Ser 334	Cys 334	engineered mutation
Ser 369	Cys 369	engineered mutation
Ser 481	Cys 481	engineered mutation
Asp 501	-	expression tag
Asp 502	-	expression tag

C, D: 601 - 613 (UniProt: Q15788)

PDB	External Database	Details
Ser 601	Gln 628	conflict
Gly 602	Thr 629	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	58178.3
Non-Polymers*	Number of molecules	2
	Total formula weight	478.5
All*	Total formula weight	58656.9

*Water molecules are not included.