7XSU

Cardiac sodium channel in complex with LqhIII

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sodium channel protein type 5 subunit alpha,G protein/GFP fusion protein	polymer	1838	209037.8	1	UniProt (P15389) UniProt (B7UCZ6) Pfam (PF00520) Pfam (PF06512) Pfam (PF01353)	Rattus norvegicus (Norway rat)	Sodium channel protein cardiac muscle subunit alpha,Sodium channel protein type V subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.5
2	B (B)	Alpha-like toxin Lqh3	polymer	67	7066.0	1	UniProt (P56678) Pfam (PF00537)	Leiurus quinquestriatus hebraeus	Lqh III,LqhIII
3	C, D, E, F, G (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
4	H (A)	beta-D-mannopyranose	non-polymer		180.2	1	Chemie (BMA)
5	I, J, K, L, M... (A)	[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate	non-polymer		718.0	6	Chemie (6OU)
6	O (A)	(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en	non-polymer		544.8	1	Chemie (9Z9)

Sequence modifications

A: 1 - 658 (UniProt: P15389)
A: 659 - 1189 (UniProt: P15389)
A: 1190 - 1898 (UniProt: P15389)

PDB	External Database	Details
Glu 1899	-	linker
Val 1900	-	linker
Leu 1901	-	linker
Phe 1902	-	linker
Gln 1903	-	linker
Gly 1904	-	linker
Pro 1905	-	linker
Gly 1906	-	linker
Ser 1907	-	linker

A: 1908 - 2146 (UniProt: B7UCZ6)

PDB	External Database	Details
Gly 2147	-	expression tag
Ser 2148	-	expression tag
Asp 2149	-	expression tag
Tyr 2150	-	expression tag
Lys 2151	-	expression tag
Asp 2152	-	expression tag
Asp 2153	-	expression tag
Asp 2154	-	expression tag
Asp 2155	-	expression tag
Lys 2156	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	216103.8
Non-Polymers*	Number of molecules	13
	Total formula weight	6139.0
All*	Total formula weight	222242.7

*Water molecules are not included.