Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7XSU

Cardiac sodium channel in complex with LqhIII

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001518	cellular_component	voltage-gated sodium channel complex
A	0005216	molecular_function	monoatomic ion channel activity
A	0005248	molecular_function	voltage-gated sodium channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0006091	biological_process	generation of precursor metabolites and energy
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0008218	biological_process	bioluminescence
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005576	cellular_component	extracellular region
B	0006952	biological_process	defense response
B	0008200	molecular_function	ion channel inhibitor activity
B	0017080	molecular_function	sodium channel regulator activity
B	0019871	molecular_function	sodium channel inhibitor activity
B	0035821	biological_process	modulation of process of another organism
B	0090729	molecular_function	toxin activity
B	0099106	molecular_function	ion channel regulator activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	199
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	78
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	75
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	14
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"UniProtKB","id":"D0E0C2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	1
Details	Site: {"description":"Cys residue near the selectivity filter, which has a free thiol that is susceptible to reaction with methanethiosulfonate (MTSET); Sodium current is irreversibly blocked by MTSET","evidences":[{"source":"UniProtKB","id":"P04775","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"26039939","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	11
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"31866066","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6UZ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	64
Details	Domain: {"description":"LCN-type CS-alpha/beta","evidences":[{"source":"PROSITE-ProRule","id":"PRU01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"Serine amide","evidences":[{"source":"PubMed","id":"9690781","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)