7XMR
CryoEM structure of the somatostatin receptor 2 (SSTR2) in complex with Gi1 and its endogeneous peptide ligand SST-14
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Somatostatin receptor type 2 | polymer | 406 | 45308.6 | 1 | UniProt (P30874) Pfam (PF00001) In PDB | Homo sapiens (human) | SS-2-R,SS2-R,SS2R,SRIF-1 |
2 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40435.1 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
4 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | L | Somatostatin-14 | polymer | 14 | 1641.9 | 1 | UniProt (P61278) Pfam (PF03002) In PDB | Homo sapiens | SST14 |
Sequence modifications
R: 2 - 359 (UniProt: P30874)
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Asp -8 | - | expression tag |
Tyr -7 | - | expression tag |
Lys -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Gly -1 | - | expression tag |
Ala 0 | - | expression tag |
Pro 1 | - | expression tag |
Glu 360 | - | expression tag |
Phe 361 | - | expression tag |
Leu 362 | - | expression tag |
Glu 363 | - | expression tag |
Val 364 | - | expression tag |
Leu 365 | - | expression tag |
Phe 366 | - | expression tag |
Gln 367 | - | expression tag |
Gly 368 | - | expression tag |
Pro 369 | - | expression tag |
Trp 370 | - | expression tag |
Ser 371 | - | expression tag |
His 372 | - | expression tag |
Pro 373 | - | expression tag |
Gln 374 | - | expression tag |
Phe 375 | - | expression tag |
Glu 376 | - | expression tag |
Lys 377 | - | expression tag |
Gly 378 | - | expression tag |
Gly 379 | - | expression tag |
Gly 380 | - | expression tag |
Ser 381 | - | expression tag |
Gly 382 | - | expression tag |
Gly 383 | - | expression tag |
Gly 384 | - | expression tag |
Ser 385 | - | expression tag |
Gly 386 | - | expression tag |
Gly 387 | - | expression tag |
Ser 388 | - | expression tag |
Ala 389 | - | expression tag |
Trp 390 | - | expression tag |
Ser 391 | - | expression tag |
His 392 | - | expression tag |
Pro 393 | - | expression tag |
Gln 394 | - | expression tag |
Phe 395 | - | expression tag |
Glu 396 | - | expression tag |
Lys 397 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Cys 47 | Ser 47 | engineered mutation |
Thr 55 | Ile 55 | conflict |
Thr 202 | Gly 202 | engineered mutation |
Ala 203 | Gly 203 | engineered mutation |
Ala 245 | Glu 245 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 133991.1 | |
All* | Total formula weight | 133991.1 |