7XMF
Cryo-EM structure of human NaV1.7/beta1/beta2-Nav1.7-IN2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Isoform 3 of Sodium channel protein type 9 subunit alpha,Green fluorescent protein | polymer | 2250 | 255679.9 | 1 | UniProt (Q15858) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512) Pfam (PF08016) In PDB | Homo sapiens (human) | |
2 | B | Sodium channel subunit beta-1,Green fluorescent protein | polymer | 481 | 54472.1 | 1 | UniProt (Q07699) Pfam (PF07686) In PDB | Homo sapiens (human) | |
3 | C | Sodium channel subunit beta-2 | polymer | 215 | 24355.9 | 1 | UniProt (O60939) Pfam (PF07686) In PDB | Homo sapiens (human) | Nav1.7 beta2 subunit |
4 | D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
5 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
6 | A | 3-[[4-[3-(4-fluoranyl-2-methyl-phenoxy)azetidin-1-yl]pyrimidin-2-yl]amino]-~{N}-methyl-benzamide | non-polymer | 407.4 | 1 | Chemie (G2W) |
Sequence modifications
A: 1 - 1988 (UniProt: Q15858)
A: 2001 - 2261 (PDB: 7XMF)
B: 1 - 218 (UniProt: Q07699)
B: 231 - 481 (PDB: 7XMF)
PDB | External Database | Details |
---|---|---|
Arg 1161 | Trp 1150 | engineered mutation |
Ala 1989 | - | linker |
Ala 1990 | - | linker |
Ala 1991 | - | linker |
Leu 1992 | - | linker |
Glu 1993 | - | linker |
Val 1994 | - | linker |
Leu 1995 | - | linker |
Phe 1996 | - | linker |
Gln 1997 | - | linker |
Gly 1998 | - | linker |
Pro 1999 | - | linker |
Ser 2000 | - | linker |
B: 1 - 218 (UniProt: Q07699)
PDB | External Database | Details |
---|---|---|
Ala 219 | - | linker |
Ala 220 | - | linker |
Ala 221 | - | linker |
Leu 222 | - | linker |
Glu 223 | - | linker |
Val 224 | - | linker |
Leu 225 | - | linker |
Phe 226 | - | linker |
Gln 227 | - | linker |
Gly 228 | - | linker |
Pro 229 | - | linker |
Ser 230 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 334507.9 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1734.7 | |
All* | Total formula weight | 337091.4 |