7XMF
Cryo-EM structure of human NaV1.7/beta1/beta2-Nav1.7-IN2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001518 | cellular_component | voltage-gated sodium channel complex |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005248 | molecular_function | voltage-gated sodium channel activity |
A | 0005261 | molecular_function | monoatomic cation channel activity |
A | 0005272 | molecular_function | sodium channel activity |
A | 0005515 | molecular_function | protein binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0006091 | biological_process | generation of precursor metabolites and energy |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006814 | biological_process | sodium ion transport |
A | 0006954 | biological_process | inflammatory response |
A | 0007623 | biological_process | circadian rhythm |
A | 0008218 | biological_process | bioluminescence |
A | 0009636 | biological_process | response to toxic substance |
A | 0009791 | biological_process | post-embryonic development |
A | 0016020 | cellular_component | membrane |
A | 0019228 | biological_process | neuronal action potential |
A | 0019233 | biological_process | sensory perception of pain |
A | 0030424 | cellular_component | axon |
A | 0033268 | cellular_component | node of Ranvier |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
A | 0034702 | cellular_component | monoatomic ion channel complex |
A | 0035725 | biological_process | sodium ion transmembrane transport |
A | 0042995 | cellular_component | cell projection |
A | 0043005 | cellular_component | neuron projection |
A | 0043679 | cellular_component | axon terminus |
A | 0048266 | biological_process | behavioral response to pain |
A | 0050965 | biological_process | detection of temperature stimulus involved in sensory perception of pain |
A | 0050974 | biological_process | detection of mechanical stimulus involved in sensory perception |
A | 0055085 | biological_process | transmembrane transport |
A | 0086002 | biological_process | cardiac muscle cell action potential involved in contraction |
A | 0098870 | biological_process | action potential propagation |
B | 0001518 | cellular_component | voltage-gated sodium channel complex |
B | 0006091 | biological_process | generation of precursor metabolites and energy |
B | 0006814 | biological_process | sodium ion transport |
B | 0008218 | biological_process | bioluminescence |
B | 0017080 | molecular_function | sodium channel regulator activity |
C | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 129 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
C | MET30-ALA159 | |
A | LYS1465-LEU1527 | |
A | VAL1576-ILE1587 | |
A | ALA1636-VAL1654 | |
A | ARG174-PRO187 | |
A | PRO229-ASP247 | |
A | VAL400-VAL755 | |
A | VAL806-SER819 | |
A | GLY860-ILE875 | |
A | ILE979-LEU1204 | |
A | THR1255-VAL1268 | |
A | ILE1315-PHE1331 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
C | VAL160-VAL180 |
site_id | SWS_FT_FI3 |
Number of Residues | 34 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
C | LYS181-LYS215 | |
A | SER1288-LEU1295 | |
A | ASN1352-ALA1403 | |
A | LYS1426-ILE1442 | |
A | VAL1546-ILE1556 | |
A | PRO1606-GLY1618 | |
A | ASP1673-ILE1694 | |
A | LYS1718-SER1747 | |
A | ASN206-SER211 | |
A | MET268-THR346 | |
A | ARG372-TYR378 | |
A | VAL775-GLY785 | |
A | LEU840-ARG841 | |
A | CYS895-VAL923 | |
A | LEU945-LEU957 | |
A | LYS1223-TYR1235 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Binds SCN2A => ECO:0000305|PubMed:30765605 |
Chain | Residue | Details |
C | TYR56 | |
C | ARG135 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P54900 |
Chain | Residue | Details |
C | SER192 | |
B | ASN114 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P54900 |
Chain | Residue | Details |
C | THR204 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
C | ASN42 | |
C | ASN74 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30765606, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J |
Chain | Residue | Details |
C | ASN66 | |
A | LEU924-CYS944 | |
A | THR1404-PRO1425 | |
A | THR1695-PRO1717 |
site_id | SWS_FT_FI9 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | MET379-ALA399 |
site_id | SWS_FT_FI10 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | LEU756-ASN774 |
site_id | SWS_FT_FI11 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ILE786-GLN805 |
site_id | SWS_FT_FI12 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | LEU820-LEU839 |
site_id | SWS_FT_FI13 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | VAL842-ILE859 |
site_id | SWS_FT_FI14 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ILE876-GLU894 |
site_id | SWS_FT_FI15 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | VAL958-ALA978 |
site_id | SWS_FT_FI16 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | SER1205-ILE1222 |
site_id | SWS_FT_FI17 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ILE1236-PHE1254 |
site_id | SWS_FT_FI18 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | SER1269-LYS1287 |
site_id | SWS_FT_FI19 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ARG1296-LEU1314 |
site_id | SWS_FT_FI20 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | TRP1332-ILE1351 |
site_id | SWS_FT_FI21 |
Number of Residues | 21 |
Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | PHE1443-LYS1464 |
site_id | SWS_FT_FI22 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ASN1528-GLU1545 |
site_id | SWS_FT_FI23 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | LEU1557-THR1575 |
site_id | SWS_FT_FI24 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ILE1588-SER1605 |
site_id | SWS_FT_FI25 |
Number of Residues | 16 |
Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | ARG1619-PHE1635 |
site_id | SWS_FT_FI26 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | MET1655-GLU1672 |
site_id | SWS_FT_FI27 |
Number of Residues | 22 |
Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
A | PHE1748-SER1770 |
site_id | SWS_FT_FI28 |
Number of Residues | 2 |
Details | SITE: Is directly targeted by the spider protoxin-II => ECO:0000269|PubMed:30661758 |
Chain | Residue | Details |
A | VAL833 | |
A | ARG838 |
site_id | SWS_FT_FI29 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:25240195 |
Chain | Residue | Details |
A | GLY1501 |
site_id | SWS_FT_FI30 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN209 |
site_id | SWS_FT_FI31 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30765606, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J |
Chain | Residue | Details |
A | ASN283 | |
A | GLN1363 | |
A | SER1377 | |
A | LYS1386 |