7XM7

Crystal Structure of the CBP in complex with the Y08188

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	CREB-binding protein	polymer	133	15891.3	4	UniProt (Q92793) Pfam (PF00439) In PDB	Homo sapiens (human)
2	A, B	3-ethanoyl-~{N}-[2-fluoranyl-3-(1-methylpyrazol-4-yl)phenyl]-7-methoxy-indolizine-1-carboxamide	non-polymer		406.4	2	Chemie (GAY)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	B, C	NITRATE ION	non-polymer		62.0	2	Chemie (NO3)
5	B	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
6	C	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
7	D	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
8		water	water		18.0	72	Chemie (HOH)

Sequence modifications

A, B, C, D: 1081 - 1197 (UniProt: Q92793)

PDB	External Database	Details
Met 1065	-	expression tag
Lys 1066	-	expression tag
Lys 1067	-	expression tag
Gly 1068	-	expression tag
His 1069	-	expression tag
His 1070	-	expression tag
His 1071	-	expression tag
His 1072	-	expression tag
His 1073	-	expression tag
His 1074	-	expression tag
Leu 1075	-	expression tag
Val 1076	-	expression tag
Pro 1077	-	expression tag
Arg 1078	-	expression tag
Gly 1079	-	expression tag
Ser 1080	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	63565.2
Non-Polymers*	Number of molecules	9
	Total formula weight	1337.3
All*	Total formula weight	64902.5

*Water molecules are not included.