7XKT

Human Cx36/GJD2 (BRIL-fused mutant) gap junction channel in detergents at 2.2 Angstroms resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Gap junction delta-2 protein,Soluble cytochrome b562	polymer	358	40999.2	12	UniProt (Q9UKL4) UniProt (P0ABE7) Pfam (PF00029) Pfam (PF07361)	Homo sapiens (human)	Connexin-36,Cx36,Gap junction alpha-9 protein,Cytochrome b-562
2	AC, AD, BA, BD, CA... (H, K, B, E, C...)	1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		677.9	72	Chemie (MC3)
3	AA, AB, BB, BC, CC... (B, E, H, K, C...)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	24	Chemie (Y01)
4	DA, EB, FC, GD, MA... (B, E, H, K, C...)	1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE	non-polymer		723.0	12	Chemie (LHG)
5	AE, BE, QD, RD, SD... (K, L, A, B, C...)	water	water		18.0	444	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 1 - 101 (UniProt: Q9UKL4)
A, B, C, D, E, F, G, H, I, J, K, L: 101 - 105 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 101	Met 29	engineered mutation
Ile 105	His 124	engineered mutation
Leu 105	Arg 128	engineered mutation

A, B, C, D, E, F, G, H, I, J, K, L: 105 - 321 (UniProt: Q9UKL4)

PDB	External Database	Details
Ser 322	-	expression tag
Arg 323	-	expression tag
Asp 324	-	expression tag
Tyr 325	-	expression tag
Lys 326	-	expression tag
Asp 327	-	expression tag
Asp 328	-	expression tag
Asp 329	-	expression tag
Asp 330	-	expression tag
Lys 331	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	491990.4
Non-Polymers*	Number of molecules	108
	Total formula weight	69168.2
All*	Total formula weight	561158.6

*Water molecules are not included.