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7XKT

Human Cx36/GJD2 (BRIL-fused mutant) gap junction channel in detergents at 2.2 Angstroms resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0005506molecular_functioniron ion binding
A0005922cellular_componentconnexin complex
A0007154biological_processcell communication
A0009055molecular_functionelectron transfer activity
A0020037molecular_functionheme binding
A0022900biological_processelectron transport chain
A0042597cellular_componentperiplasmic space
A0046872molecular_functionmetal ion binding
B0005506molecular_functioniron ion binding
B0005922cellular_componentconnexin complex
B0007154biological_processcell communication
B0009055molecular_functionelectron transfer activity
B0020037molecular_functionheme binding
B0022900biological_processelectron transport chain
B0042597cellular_componentperiplasmic space
B0046872molecular_functionmetal ion binding
C0005506molecular_functioniron ion binding
C0005922cellular_componentconnexin complex
C0007154biological_processcell communication
C0009055molecular_functionelectron transfer activity
C0020037molecular_functionheme binding
C0022900biological_processelectron transport chain
C0042597cellular_componentperiplasmic space
C0046872molecular_functionmetal ion binding
D0005506molecular_functioniron ion binding
D0005922cellular_componentconnexin complex
D0007154biological_processcell communication
D0009055molecular_functionelectron transfer activity
D0020037molecular_functionheme binding
D0022900biological_processelectron transport chain
D0042597cellular_componentperiplasmic space
D0046872molecular_functionmetal ion binding
E0005506molecular_functioniron ion binding
E0005922cellular_componentconnexin complex
E0007154biological_processcell communication
E0009055molecular_functionelectron transfer activity
E0020037molecular_functionheme binding
E0022900biological_processelectron transport chain
E0042597cellular_componentperiplasmic space
E0046872molecular_functionmetal ion binding
F0005506molecular_functioniron ion binding
F0005922cellular_componentconnexin complex
F0007154biological_processcell communication
F0009055molecular_functionelectron transfer activity
F0020037molecular_functionheme binding
F0022900biological_processelectron transport chain
F0042597cellular_componentperiplasmic space
F0046872molecular_functionmetal ion binding
G0005506molecular_functioniron ion binding
G0005922cellular_componentconnexin complex
G0007154biological_processcell communication
G0009055molecular_functionelectron transfer activity
G0020037molecular_functionheme binding
G0022900biological_processelectron transport chain
G0042597cellular_componentperiplasmic space
G0046872molecular_functionmetal ion binding
H0005506molecular_functioniron ion binding
H0005922cellular_componentconnexin complex
H0007154biological_processcell communication
H0009055molecular_functionelectron transfer activity
H0020037molecular_functionheme binding
H0022900biological_processelectron transport chain
H0042597cellular_componentperiplasmic space
H0046872molecular_functionmetal ion binding
I0005506molecular_functioniron ion binding
I0005922cellular_componentconnexin complex
I0007154biological_processcell communication
I0009055molecular_functionelectron transfer activity
I0020037molecular_functionheme binding
I0022900biological_processelectron transport chain
I0042597cellular_componentperiplasmic space
I0046872molecular_functionmetal ion binding
J0005506molecular_functioniron ion binding
J0005922cellular_componentconnexin complex
J0007154biological_processcell communication
J0009055molecular_functionelectron transfer activity
J0020037molecular_functionheme binding
J0022900biological_processelectron transport chain
J0042597cellular_componentperiplasmic space
J0046872molecular_functionmetal ion binding
K0005506molecular_functioniron ion binding
K0005922cellular_componentconnexin complex
K0007154biological_processcell communication
K0009055molecular_functionelectron transfer activity
K0020037molecular_functionheme binding
K0022900biological_processelectron transport chain
K0042597cellular_componentperiplasmic space
K0046872molecular_functionmetal ion binding
L0005506molecular_functioniron ion binding
L0005922cellular_componentconnexin complex
L0007154biological_processcell communication
L0009055molecular_functionelectron transfer activity
L0020037molecular_functionheme binding
L0022900biological_processelectron transport chain
L0042597cellular_componentperiplasmic space
L0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTlQPGCnqACYD
ChainResidueDetails
ACYS55-ASP68

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Cnry.PCikeVECYVSRP
ChainResidueDetails
ACYS231-PRO247

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues756
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-SER19
EGLY276-VAL321
FMET1-SER19
FGLY276-VAL321
GMET1-SER19
GGLY276-VAL321
HMET1-SER19
HGLY276-VAL321
IMET1-SER19
IGLY276-VAL321
JMET1-SER19
AGLY276-VAL321
JGLY276-VAL321
KMET1-SER19
KGLY276-VAL321
LMET1-SER19
LGLY276-VAL321
BMET1-SER19
BGLY276-VAL321
CMET1-SER19
CGLY276-VAL321
DMET1-SER19
DGLY276-VAL321
EMET1-SER19

site_idSWS_FT_FI2
Number of Residues1056
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ATHR20-GLY42
CILE76-VAL98
CPHE198-LEU220
CPHE253-LEU275
DTHR20-GLY42
DILE76-VAL98
DPHE198-LEU220
DPHE253-LEU275
ETHR20-GLY42
EILE76-VAL98
EPHE198-LEU220
AILE76-VAL98
EPHE253-LEU275
FTHR20-GLY42
FILE76-VAL98
FPHE198-LEU220
FPHE253-LEU275
GTHR20-GLY42
GILE76-VAL98
GPHE198-LEU220
GPHE253-LEU275
HTHR20-GLY42
APHE198-LEU220
HILE76-VAL98
HPHE198-LEU220
HPHE253-LEU275
ITHR20-GLY42
IILE76-VAL98
IPHE198-LEU220
IPHE253-LEU275
JTHR20-GLY42
JILE76-VAL98
JPHE198-LEU220
APHE253-LEU275
JPHE253-LEU275
KTHR20-GLY42
KILE76-VAL98
KPHE198-LEU220
KPHE253-LEU275
LTHR20-GLY42
LILE76-VAL98
LPHE198-LEU220
LPHE253-LEU275
BTHR20-GLY42
BILE76-VAL98
BPHE198-LEU220
BPHE253-LEU275
CTHR20-GLY42

site_idSWS_FT_FI3
Number of Residues756
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLU43-HIS75
ETYR221-VAL252
FGLU43-HIS75
FTYR221-VAL252
GGLU43-HIS75
GTYR221-VAL252
HGLU43-HIS75
HTYR221-VAL252
IGLU43-HIS75
ITYR221-VAL252
JGLU43-HIS75
ATYR221-VAL252
JTYR221-VAL252
KGLU43-HIS75
KTYR221-VAL252
LGLU43-HIS75
LTYR221-VAL252
BGLU43-HIS75
BTYR221-VAL252
CGLU43-HIS75
CTYR221-VAL252
DGLU43-HIS75
DTYR221-VAL252
EGLU43-HIS75

site_idSWS_FT_FI4
Number of Residues24
DetailsBINDING: axial binding residue
ChainResidueDetails
ATRP101
EILE105
FTRP101
FILE105
GTRP101
GILE105
HTRP101
HILE105
ITRP101
IILE105
JTRP101
AILE105
JILE105
KTRP101
KILE105
LTRP101
LILE105
BTRP101
BILE105
CTRP101
CILE105
DTRP101
DILE105
ETRP101

222036

PDB entries from 2024-07-03

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