7XHN
Structure of human inner kinetochore CCAN-DNA complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, H (o, O) | Centromere protein O | polymer | 300 | 33830.6 | 2 | UniProt (Q9BU64) Pfam (PF09496) | Homo sapiens (human) | CENP-O,Interphase centromere complex protein 36 |
| 2 | B (H) | Centromere protein H | polymer | 253 | 29349.8 | 1 | UniProt (Q9H3R5) Pfam (PF05837) | Homo sapiens (human) | CENP-H,Interphase centromere complex protein 35 |
| 3 | C (I) | Centromere protein I | polymer | 756 | 86820.2 | 1 | UniProt (Q92674) Pfam (PF07778) | Homo sapiens (human) | CENP-I,FSH primary response protein 1,Follicle-stimulating hormone primary response protein,Interphase centromere complex protein 19,Leucine-rich primary response protein 1 |
| 4 | D (K) | Centromere protein K | polymer | 269 | 31696.1 | 1 | UniProt (Q9BS16) Pfam (PF11802) | Homo sapiens (human) | CENP-K,Interphase centromere complex protein 37,Protein AF-5alpha,p33 |
| 5 | E (L) | Centromere protein L | polymer | 344 | 39039.6 | 1 | UniProt (Q8N0S6) Pfam (PF13092) | Homo sapiens (human) | CENP-L,Interphase centromere complex protein 33 |
| 6 | F (M) | Centromere protein M | polymer | 180 | 19761.9 | 1 | UniProt (Q9NSP4) Pfam (PF11111) | Homo sapiens (human) | CENP-M,Interphase centromere complex protein 39,Proliferation-associated nuclear element protein 1 |
| 7 | G (N) | Centromere protein N | polymer | 345 | 40438.4 | 1 | UniProt (Q96H22) Pfam (PF05238) | Homo sapiens (human) | CENP-N,Interphase centromere complex protein 32 |
| 8 | I (P) | Centromere protein P | polymer | 288 | 33210.9 | 1 | UniProt (Q6IPU0) Pfam (PF13096) | Homo sapiens (human) | CENP-P |
| 9 | J (S) | Centromere protein S | polymer | 138 | 15917.9 | 1 | UniProt (Q8N2Z9) Pfam (PF15630) | Homo sapiens (human) | CENP-S,Apoptosis-inducing TAF9-like domain-containing protein 1,FANCM-associated histone fold protein 1,FANCM-interacting histone fold protein 1,Fanconi anemia-associated polypeptide of 16 kDa |
| 10 | K (T) | Centromere protein T | polymer | 561 | 60502.6 | 1 | UniProt (Q96BT3) Pfam (PF16171) Pfam (PF15511) | Homo sapiens (human) | CENP-T,Interphase centromere complex protein 22 |
| 11 | L (W) | CENP-W | polymer | 88 | 10087.2 | 1 | UniProt (Q5EE01) Pfam (PF15510) | Homo sapiens (human) | |
| 12 | M (X) | Centromere protein X | polymer | 81 | 8972.4 | 1 | UniProt (A8MT69) Pfam (PF09415) | Homo sapiens (human) | CENP-X,FANCM-associated histone fold protein 2,FANCM-interacting histone fold protein 2,Fanconi anemia-associated polypeptide of 10 kDa,Retinoic acid-inducible gene D9 protein homolog,Stimulated by retinoic acid gene 13 protein homolog |
| 13 | N (G) | DNA (25-MER) | polymer | 25 | 7685.9 | 1 | Homo sapiens | ||
| 14 | O (J) | DNA (25-MER) | polymer | 25 | 7676.9 | 1 | Homo sapiens | ||
| 15 | P, Q (C, c) | Centromere protein C | polymer | 943 | 107022.3 | 2 | UniProt (Q03188) Pfam (PF15622) Pfam (PF15620) Pfam (PF11699) | Homo sapiens (human) | CENP-C,Centromere autoantigen C,Centromere protein C 1,CENP-C 1,Interphase centromere complex protein 7 |
| 16 | R (Q) | Centromere protein Q | polymer | 274 | 31477.2 | 1 | UniProt (Q7L2Z9) Pfam (PF13094) | Homo sapiens (human) | CENP-Q |
| 17 | S (U) | Centromere protein U | polymer | 418 | 47609.8 | 1 | UniProt (Q71F23) Pfam (PF13097) | Homo sapiens (human) | CENP-U,Centromere protein of 50 kDa,CENP-50,Interphase centromere complex protein 24,KSHV latent nuclear antigen-interacting protein 1,MLF1-interacting protein,Polo-box-interacting protein 1 |
| 18 | T (R) | Centromere protein R | polymer | 177 | 20228.3 | 1 | UniProt (Q13352) Pfam (PF06729) | Homo sapiens (human) | CENP-R,Beta-3-endonexin,Integrin beta-3-binding protein,Nuclear receptor-interacting factor 3 |
Sequence modifications
H: 1 - 247 (UniProt: Q9H3R5)
N: 1 - 339 (UniProt: Q96H22)
Q: 1 - 268 (UniProt: Q7L2Z9)
| PDB | External Database | Details |
|---|---|---|
| His 248 | - | expression tag |
| His 249 | - | expression tag |
| His 250 | - | expression tag |
| His 251 | - | expression tag |
| His 252 | - | expression tag |
| His 253 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 340 | - | expression tag |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 269 | - | expression tag |
| His 270 | - | expression tag |
| His 271 | - | expression tag |
| His 272 | - | expression tag |
| His 273 | - | expression tag |
| His 274 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 772181.1 | |
| All* | Total formula weight | 772181.1 |
