7XGE
Crystal structure of MCL-1 in complex with computationally designed inhibitor protein
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G | BCL-xL and MCL-1 dual binder 2 | polymer | 169 | 19149.3 | 4 | synthetic construct | ||
2 | B, D, F, H | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 156 | 17867.5 | 4 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
3 | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
B, D, F, H: 4 - 153 (UniProt: Q07820)
PDB | External Database | Details |
---|---|---|
Met 3 | - | initiating methionine |
Ser 154 | - | expression tag |
Arg 155 | - | expression tag |
Gly 156 | - | expression tag |
Lys 157 | - | expression tag |
Leu 158 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 148067.2 | |
All* | Total formula weight | 148067.2 |