7XFR

Crystal structure of WIPI2b in complex with the second site of ATG16L1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2	polymer	321	35310.6	2	UniProt (Q9Y4P8-2) Pfam (PF21032) UniProt (by SIFTS) (Q9Y4P8)	Homo sapiens (human)	WIPI-2,WIPI49-like protein 2
2	B, D (B, D)	Autophagy-related protein 16-1	polymer	69	7815.8	2	UniProt (Q676U5) Pfam (PF08614)	Homo sapiens (human)	APG16-like 1
3	E, F, G, H (A, B, C, D)	water	water		18.0	424	Chemie (HOH)

Sequence modifications

A, C: 13 - 362 (UniProt: Q9Y4P8-2)

PDB	External Database	Details
Gly 9	-	expression tag
Pro 10	-	expression tag
Gly 11	-	expression tag
Ser 12	-	expression tag
-	Lys 265	deletion
-	Pro 266	deletion
-	Pro 267	deletion
-	Glu 268	deletion
-	Glu 269	deletion
-	Pro 270	deletion
-	Thr 271	deletion
-	Thr 272	deletion
-	Trp 273	deletion
-	Thr 274	deletion
-	Gly 275	deletion
-	Tyr 276	deletion
-	Phe 277	deletion
-	Gly 278	deletion
-	Lys 279	deletion
-	Val 280	deletion
-	Leu 281	deletion
-	Met 282	deletion
-	Ala 283	deletion
-	Ser 284	deletion
-	Thr 285	deletion
-	Ser 286	deletion
-	Tyr 287	deletion
-	Leu 288	deletion
-	Pro 289	deletion
-	Ser 290	deletion
-	Gln 291	deletion
-	Val 292	deletion
-	Thr 293	deletion
-	Glu 294	deletion
-	Met 295	deletion
-	Phe 296	deletion
-	Asn 297	deletion

B, D: 124 - 188 (UniProt: Q676U5)

PDB	External Database	Details
Gly 120	-	expression tag
Pro 121	-	expression tag
Gly 122	-	expression tag
Ser 123	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	86252.8
All*	Total formula weight	86252.8

*Water molecules are not included.