7XAV

Structure of somatostatin receptor 2 bound with lanreotide.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Somatostatin receptor type 2,LargeBit	polymer	563	63274.4	1	UniProt (P30874) Pfam (PF00001)	Homo sapiens (human)	SS-2-R,SS2-R,SS2R,SRIF-1
2	B (B)	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	354	40472.1	1	UniProt (P63096) Pfam (PF00503)	Homo sapiens (human)	Adenylate cyclase-inhibiting G alpha protein
3	C (C)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	354	38975.6	1	UniProt (P62871) Pfam (PF00400)	Bos taurus (cattle)	Transducin beta chain 1
4	D (D)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P63212) Pfam (PF00631)	Bos taurus (cattle)	G gamma-I
5	E (E)	ScFv16	polymer	304	32768.5	1		Rattus
6	F (F)	Lanreotide	polymer	9	1098.3	1		synthetic construct

Sequence modifications

A: 1 - 359 (UniProt: P30874)

PDB	External Database	Details
Met -45	-	initiating methionine
Lys -44	-	expression tag
Thr -43	-	expression tag
Ile -42	-	expression tag
Ile -41	-	expression tag
Ala -40	-	expression tag
Leu -39	-	expression tag
Ser -38	-	expression tag
Tyr -37	-	expression tag
Ile -36	-	expression tag
Phe -35	-	expression tag
Cys -34	-	expression tag
Leu -33	-	expression tag
Val -32	-	expression tag
Phe -31	-	expression tag
Ala -30	-	expression tag
Asp -29	-	expression tag
Tyr -28	-	expression tag
Lys -27	-	expression tag
Asp -26	-	expression tag
Asp -25	-	expression tag
Asp -24	-	expression tag
Asp -23	-	expression tag
Lys -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

A: 360 - 517 (PDB: 7XAV)
B: 1 - 354 (UniProt: P63096)

PDB	External Database	Details
Asn 47	Ser 47	conflict
Ala 203	Gly 203	conflict
Ser 326	Ala 326	conflict

C: 2 - 340 (UniProt: P62871)

PDB	External Database	Details
Met -10	-	initiating methionine
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag
Gly 341	-	expression tag
Ser 342	-	expression tag
Ser 343	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	184450.0
All*	Total formula weight	184450.0

*Water molecules are not included.