7WVJ

NT-mut(K117D,K139D,K145D) TLR3 -poly I:C complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Toll-like receptor 3	polymer	689	78381.1	2	UniProt (O15455) Pfam (PF13855) Pfam (PF13516) Pfam (PF00560) In PDB	Homo sapiens (human)
2	E	RNA (46-MER)	polymer	46	13993.4	1		synthetic construct
3	F	RNA (46-MER)	polymer	46	15143.8	1		synthetic construct

Sequence modifications

A, B: 27 - 697 (UniProt: O15455)

PDB	External Database	Details
Ala 24	-	expression tag
Asp 25	-	expression tag
Pro 26	-	expression tag
Asp 117	Lys 117	engineered mutation
Asp 139	Lys 139	engineered mutation
Asp 145	Lys 145	engineered mutation
Ser 698	-	expression tag
Gly 699	-	expression tag
Arg 700	-	expression tag
Leu 701	-	expression tag
Val 702	-	expression tag
Pro 703	-	expression tag
Arg 704	-	expression tag
Gly 705	-	expression tag
Ser 706	-	expression tag
His 707	-	expression tag
His 708	-	expression tag
His 709	-	expression tag
His 710	-	expression tag
His 711	-	expression tag
His 712	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	185899.4
All*	Total formula weight	185899.4

*Water molecules are not included.