7WUH
SARS-CoV-2 Spike in complex with Fab of m31A7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, C, E) | Spike glycoprotein | polymer | 1242 | 137495.1 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
| 2 | D, F, H (D, H, K) | m31A7 Fab heavy chain | polymer | 239 | 25621.9 | 3 | Homo sapiens | ||
| 3 | E, G, I (F, I, L) | m31A7 Fab light chain | polymer | 240 | 26564.0 | 3 | Homo sapiens | ||
| 4 | BA, J (b, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
| 5 | K, N, O, P, R... (G, N, O, P, R...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 8 | In PDB GlyTouCan (G42666HT) | |||
| 6 | L, Y (J, Y) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
| 7 | EA, M, Q, Z (e, M, Q, Z) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 8 | S, W (S, W) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 9 | U (U) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G94626GC) | |||
| 10 | AA, GA (a, g) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 2 | In PDB GlyTouCan (G32152BH) | |||
| 11 | CA (c) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 12 | DA (d) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 1 | In PDB | |||
| 13 | FA (f) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G54064FW) | |||
| 14 | HA, IA, JA, KA, LA... (A, C, E, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 19 | Chemie (NAG) |
Sequence modifications
A, C, E: 14 - 1208 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Gly 614 | Asp 614 | engineered mutation |
| Gly 682 | Arg 682 | variant |
| Ser 683 | Arg 683 | variant |
| Gly 685 | Arg 685 | variant |
| Pro 986 | Lys 986 | variant |
| Pro 987 | Val 987 | variant |
| Asp 1209 | - | expression tag |
| Ile 1210 | - | expression tag |
| Arg 1211 | - | expression tag |
| Ser 1212 | - | expression tag |
| Leu 1213 | - | expression tag |
| Val 1214 | - | expression tag |
| Pro 1215 | - | expression tag |
| Arg 1216 | - | expression tag |
| Gly 1217 | - | expression tag |
| Ser 1218 | - | expression tag |
| Pro 1219 | - | expression tag |
| Gly 1220 | - | expression tag |
| Ser 1221 | - | expression tag |
| Gly 1222 | - | expression tag |
| Tyr 1223 | - | expression tag |
| Ile 1224 | - | expression tag |
| Pro 1225 | - | expression tag |
| Glu 1226 | - | expression tag |
| Ala 1227 | - | expression tag |
| Pro 1228 | - | expression tag |
| Arg 1229 | - | expression tag |
| Asp 1230 | - | expression tag |
| Gly 1231 | - | expression tag |
| Gln 1232 | - | expression tag |
| Ala 1233 | - | expression tag |
| Tyr 1234 | - | expression tag |
| Val 1235 | - | expression tag |
| Arg 1236 | - | expression tag |
| Lys 1237 | - | expression tag |
| Asp 1238 | - | expression tag |
| Gly 1239 | - | expression tag |
| Glu 1240 | - | expression tag |
| Trp 1241 | - | expression tag |
| Val 1242 | - | expression tag |
| Leu 1243 | - | expression tag |
| Leu 1244 | - | expression tag |
| Ser 1245 | - | expression tag |
| Thr 1246 | - | expression tag |
| Phe 1247 | - | expression tag |
| Leu 1248 | - | expression tag |
| Gly 1249 | - | expression tag |
| His 1250 | - | expression tag |
| His 1251 | - | expression tag |
| His 1252 | - | expression tag |
| His 1253 | - | expression tag |
| His 1254 | - | expression tag |
| His 1255 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 569043.0 | |
| Branched | Number of molecules | 24 |
| Total formula weight | 15132.0 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 4203.0 | |
| All* | Total formula weight | 588377.9 |
