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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7WU5

Cryo-EM structure of the adhesion GPCR ADGRF1(H565A/T567A) in complex with miniGi

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer24127563.41UniProt (A0A3B3IUA8)
UniProt (P63096)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35138744.41UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
4D
(R)		Adhesion G-protein coupled receptor F1polymer67474513.41UniProt (Q5T601)
Pfam (PF01825)
Pfam (PF00002)		Homo sapiens (human)G protein-coupled receptor 110,G protein-coupled receptor KPG_012,G protein-coupled receptor PGR19
5E
(R)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (45044259)
PubChem (49853509)
PubChem (50990013)
PubChem (52934537)
PubChem (56621683)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (101624109)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
PubChem (176980071)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (23423981)
PubChem (44654663)
PubChem (46937002)
PubChem (59274407)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (5997)
PubChem (1551269)
PubChem (90070115)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (304)
PubChem (138967089)
PubChem (139566851)
PubChem (15939944)
PubChem (171828367)
PubChem (173516975)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (638019)
PubChem (1549081)
PubChem (1553803)
PubChem (5283629)
PubChem (5284644)
PubChem (5315842)
PubChem (6419195)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
6F
(R)		[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] hexadecanoatenon-polymer496.61Chemie (K6G)
Sequence modifications
A: 4 - 172 (UniProt: A0A3B3IUA8)
PDBExternal DatabaseDetails
Met -11-initiating methionine
Gly -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
Glu -3-expression tag
Asn -2-expression tag
Leu -1-expression tag
Tyr 0-expression tag
Phe 1-expression tag
Gln 2-expression tag
Gly 3-expression tag
Asp 42Gly 42conflict
Asn 43Glu 43conflict
Gly 173-linker
Gly 174-linker
Gly 175-linker
Gly 176-linker
Gly 177-linker
Gly 178-linker
Gly 179-linker
Gly 180-linker
A: 181 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Asp 217Gly 217conflict
Ala 219Thr 219conflict
Asp 226Ala 226conflict
-Asp 231deletion
-Leu 232deletion
-Val 233deletion
-Leu 234deletion
-Ala 235deletion
-Glu 236deletion
-Asp 237deletion
-Glu 238deletion
-Glu 239deletion
-Met 240deletion
Gln 288Pro 288conflict
Ala 332Val 332conflict
Ile 335Val 335conflict
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
R: 251 - 860 (UniProt: Q5T601)
PDBExternal DatabaseDetails
Met 225-initiating methionine
Lys 226-expression tag
Thr 227-expression tag
Ile 228-expression tag
Ile 229-expression tag
Ala 230-expression tag
Leu 231-expression tag
Ser 232-expression tag
Tyr 233-expression tag
Ile 234-expression tag
Phe 235-expression tag
Cys 236-expression tag
Leu 237-expression tag
Val 238-expression tag
Phe 239-expression tag
Ala 240-expression tag
Asp 241-expression tag
Tyr 242-expression tag
Lys 243-expression tag
Asp 244-expression tag
Asp 245-expression tag
Asp 246-expression tag
Asp 247-expression tag
Gly 248-expression tag
Ala 249-expression tag
Pro 250-expression tag
Ala 565His 565engineered mutation
Ala 567Thr 567engineered mutation
Glu 861-expression tag
Phe 862-expression tag
Leu 863-expression tag
Glu 864-expression tag
Val 865-expression tag
Leu 866-expression tag
Phe 867-expression tag
Gln 868-expression tag
Gly 869-expression tag
Pro 870-expression tag
Trp 871-expression tag
Ser 872-expression tag
His 873-expression tag
Pro 874-expression tag
Gln 875-expression tag
Phe 876-expression tag
Glu 877-expression tag
Lys 878-expression tag
Gly 879-expression tag
Gly 880-expression tag
Gly 881-expression tag
Ser 882-expression tag
Gly 883-expression tag
Gly 884-expression tag
Gly 885-expression tag
Ser 886-expression tag
Gly 887-expression tag
Gly 888-expression tag
Ser 889-expression tag
Ala 890-expression tag
Trp 891-expression tag
Ser 892-expression tag
His 893-expression tag
Pro 894-expression tag
Gln 895-expression tag
Phe 896-expression tag
Glu 897-expression tag
Lys 898-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight148682.3
Non-Polymers*Number of molecules2
Total formula weight883.3
All*Total formula weight149565.6
*Water molecules are not included.

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PDB entries from 2026-04-15

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