7WTF

SARS-CoV-2 Omicron variant spike in complex with Fab XGv051

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H, G, I	Heavy chain of XGv051	polymer	120	13067.4	3		Homo sapiens
2	L, J, K	Light chain of XGv051	polymer	104	11241.5	3		Homo sapiens
3	B, C, D	Spike glycoprotein	polymer	1149	127791.1	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) In PDB	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein
4	b, c, A, E, N...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	15	In PDB GlyTouCan (G42666HT)
5	a, F, M, R, S	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	5	In PDB GlyTouCan (G15407YE)
6	D, B, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	30	Chemie (NAG)

Sequence modifications

B, C, D: 14 - 1164 (UniProt: P0DTC2)

PDB	External Database	Details
Val 67	Ala 67	variant
-	His 69	deletion
-	Val 70	deletion
Ile 95	Thr 95	variant
Asp 142	Gly 142	variant
-	Val 143	deletion
-	Tyr 144	deletion
-	Tyr 145	deletion
-	Asn 211	deletion
Ile 211	Leu 212	variant
Glu 214	-	insertion
Pro 215	-	insertion
Glu 216	-	insertion
Asp 341	Gly 339	variant
Leu 373	Ser 371	variant
Pro 375	Ser 373	variant
Phe 377	Ser 375	variant
Asn 419	Lys 417	variant
Lys 442	Asn 440	variant
Ser 448	Gly 446	variant
Asn 479	Ser 477	variant
Lys 480	Thr 478	variant
Ala 486	Glu 484	variant
Arg 495	Gln 493	variant
Ser 498	Gly 496	variant
Arg 500	Gln 498	variant
Tyr 503	Asn 501	variant
His 507	Tyr 505	variant
Lys 549	Thr 547	variant
Gly 616	Asp 614	variant
Tyr 657	His 655	variant
Ala 685	Arg 683	variant
Ala 687	Arg 685	variant
Lys 766	Asn 764	variant
Tyr 798	Asp 796	variant
Pro 819	Phe 817	variant
Lys 858	Asn 856	variant
Pro 894	Ala 892	variant
Pro 901	Ala 899	variant
Pro 944	Ala 942	variant
His 956	Gln 954	variant
Lys 971	Asn 969	variant
Phe 983	Leu 981	variant
Pro 988	Lys 986	engineered mutation
Pro 989	Val 987	engineered mutation
Arg 1165	-	expression tag
Arg 1166	-	expression tag
Ala 1167	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	456300.1
Branched	Number of molecules	20
	Total formula weight	9298.7
Non-Polymers*	Number of molecules	30
	Total formula weight	6636.2
All*	Total formula weight	472235.1

*Water molecules are not included.